Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer

Frank J. Penedo; Jason R. Dahn; Dave Kinsinger; Michael H. Antoni; Ivan Molton; Jeffrey S. Gonzalez; Mary Anne Fletcher; Bernard Roos; Charles S. Carver; Neil Schneiderman

doi:10.1016/j.jpsychores.2005.08.001

Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer

Frank J. Penedo, Jason R. Dahn, Dave Kinsinger, Michael H. Antoni, Ivan Molton, Jeffrey S. Gonzalez, Mary Anne Fletcher, Bernard Roos, Charles S. Carver, Neil Schneiderman

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Objective: This study evaluated relations among optimism, depression, anger suppression and natural killer cell cytotoxicity (NKCC) in 61 men treated for localized prostate cancer (PC). Method: All participants were assessed at a single time point where demographics, optimism, depression and anger suppression were measured. We also collected peripheral venous blood to assess NKCC. Results: Results showed that greater optimism was associated with greater NKCC (β=.27, P<.05), less depression (β=-.63, P<.001) and less anger suppression (β=-.29, P<.05). Furthermore, less anger suppression (β=-.35, P<.01) was associated with greater NKCC. In a hierarchical regression model controlling for depression and then anger suppression, the relationship between optimism and NKCC became nonsignificant [β=.18, t(56)=1.51, P=.14], while anger suppression remained significantly correlated with NKCC [β=-.29, t(56)=-2.40, P<.05]. Conclusions: Results suggest that optimism is associated with NKCC and a greater ability to adaptively express anger. Furthermore, it appears that less anger suppression partially mediates the relationship between optimism and NKCC.

Original language	English (US)
Pages (from-to)	423-427
Number of pages	5
Journal	Journal of Psychosomatic Research
Volume	60
Issue number	4
DOIs	https://doi.org/10.1016/j.jpsychores.2005.08.001
State	Published - Apr 2006

Keywords

Anger suppression
Depression
Natural killer cell cytotoxicity
Optimism
Prostate cancer

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry
Psychology(all)

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

Access to Document

10.1016/j.jpsychores.2005.08.001

Fingerprint Dive into the research topics of 'Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer'. Together they form a unique fingerprint.

Cite this

Penedo, F. J., Dahn, J. R., Kinsinger, D., Antoni, M. H., Molton, I., Gonzalez, J. S., Fletcher, M. A., Roos, B., Carver, C. S., & Schneiderman, N. (2006). Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer. Journal of Psychosomatic Research, 60(4), 423-427. https://doi.org/10.1016/j.jpsychores.2005.08.001

Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer. / Penedo, Frank J.; Dahn, Jason R.; Kinsinger, Dave; Antoni, Michael H.; Molton, Ivan; Gonzalez, Jeffrey S.; Fletcher, Mary Anne; Roos, Bernard; Carver, Charles S.; Schneiderman, Neil.

In: Journal of Psychosomatic Research, Vol. 60, No. 4, 04.2006, p. 423-427.

Research output: Contribution to journal › Article › peer-review

Penedo, FJ, Dahn, JR, Kinsinger, D, Antoni, MH, Molton, I, Gonzalez, JS, Fletcher, MA, Roos, B, Carver, CS & Schneiderman, N 2006, 'Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer', Journal of Psychosomatic Research, vol. 60, no. 4, pp. 423-427. https://doi.org/10.1016/j.jpsychores.2005.08.001

Penedo, Frank J. ; Dahn, Jason R. ; Kinsinger, Dave ; Antoni, Michael H. ; Molton, Ivan ; Gonzalez, Jeffrey S. ; Fletcher, Mary Anne ; Roos, Bernard ; Carver, Charles S. ; Schneiderman, Neil. / Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer. In: Journal of Psychosomatic Research. 2006 ; Vol. 60, No. 4. pp. 423-427.

@article{7f2a7436e3c643f88372169f3fe2fefd,

title = "Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer",

abstract = "Objective: This study evaluated relations among optimism, depression, anger suppression and natural killer cell cytotoxicity (NKCC) in 61 men treated for localized prostate cancer (PC). Method: All participants were assessed at a single time point where demographics, optimism, depression and anger suppression were measured. We also collected peripheral venous blood to assess NKCC. Results: Results showed that greater optimism was associated with greater NKCC (β=.27, P<.05), less depression (β=-.63, P<.001) and less anger suppression (β=-.29, P<.05). Furthermore, less anger suppression (β=-.35, P<.01) was associated with greater NKCC. In a hierarchical regression model controlling for depression and then anger suppression, the relationship between optimism and NKCC became nonsignificant [β=.18, t(56)=1.51, P=.14], while anger suppression remained significantly correlated with NKCC [β=-.29, t(56)=-2.40, P<.05]. Conclusions: Results suggest that optimism is associated with NKCC and a greater ability to adaptively express anger. Furthermore, it appears that less anger suppression partially mediates the relationship between optimism and NKCC.",

keywords = "Anger suppression, Depression, Natural killer cell cytotoxicity, Optimism, Prostate cancer",

author = "Penedo, {Frank J.} and Dahn, {Jason R.} and Dave Kinsinger and Antoni, {Michael H.} and Ivan Molton and Gonzalez, {Jeffrey S.} and Fletcher, {Mary Anne} and Bernard Roos and Carver, {Charles S.} and Neil Schneiderman",

year = "2006",

month = apr,

doi = "10.1016/j.jpsychores.2005.08.001",

language = "English (US)",

volume = "60",

pages = "423--427",

journal = "Journal of Psychosomatic Research",

issn = "0022-3999",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer

AU - Penedo, Frank J.

AU - Dahn, Jason R.

AU - Kinsinger, Dave

AU - Antoni, Michael H.

AU - Molton, Ivan

AU - Gonzalez, Jeffrey S.

AU - Fletcher, Mary Anne

AU - Roos, Bernard

AU - Carver, Charles S.

AU - Schneiderman, Neil

PY - 2006/4

Y1 - 2006/4

N2 - Objective: This study evaluated relations among optimism, depression, anger suppression and natural killer cell cytotoxicity (NKCC) in 61 men treated for localized prostate cancer (PC). Method: All participants were assessed at a single time point where demographics, optimism, depression and anger suppression were measured. We also collected peripheral venous blood to assess NKCC. Results: Results showed that greater optimism was associated with greater NKCC (β=.27, P<.05), less depression (β=-.63, P<.001) and less anger suppression (β=-.29, P<.05). Furthermore, less anger suppression (β=-.35, P<.01) was associated with greater NKCC. In a hierarchical regression model controlling for depression and then anger suppression, the relationship between optimism and NKCC became nonsignificant [β=.18, t(56)=1.51, P=.14], while anger suppression remained significantly correlated with NKCC [β=-.29, t(56)=-2.40, P<.05]. Conclusions: Results suggest that optimism is associated with NKCC and a greater ability to adaptively express anger. Furthermore, it appears that less anger suppression partially mediates the relationship between optimism and NKCC.

AB - Objective: This study evaluated relations among optimism, depression, anger suppression and natural killer cell cytotoxicity (NKCC) in 61 men treated for localized prostate cancer (PC). Method: All participants were assessed at a single time point where demographics, optimism, depression and anger suppression were measured. We also collected peripheral venous blood to assess NKCC. Results: Results showed that greater optimism was associated with greater NKCC (β=.27, P<.05), less depression (β=-.63, P<.001) and less anger suppression (β=-.29, P<.05). Furthermore, less anger suppression (β=-.35, P<.01) was associated with greater NKCC. In a hierarchical regression model controlling for depression and then anger suppression, the relationship between optimism and NKCC became nonsignificant [β=.18, t(56)=1.51, P=.14], while anger suppression remained significantly correlated with NKCC [β=-.29, t(56)=-2.40, P<.05]. Conclusions: Results suggest that optimism is associated with NKCC and a greater ability to adaptively express anger. Furthermore, it appears that less anger suppression partially mediates the relationship between optimism and NKCC.

KW - Anger suppression

KW - Depression

KW - Natural killer cell cytotoxicity

KW - Optimism

KW - Prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=33645850691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645850691&partnerID=8YFLogxK

U2 - 10.1016/j.jpsychores.2005.08.001

DO - 10.1016/j.jpsychores.2005.08.001

M3 - Article

C2 - 16581368

AN - SCOPUS:33645850691

VL - 60

SP - 423

EP - 427

JO - Journal of Psychosomatic Research

JF - Journal of Psychosomatic Research

SN - 0022-3999

IS - 4

ER -

Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Cite this