TY - JOUR
T1 - Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer
AU - Penedo, Frank J.
AU - Dahn, Jason R.
AU - Kinsinger, Dave
AU - Antoni, Michael H.
AU - Molton, Ivan
AU - Gonzalez, Jeffrey S.
AU - Fletcher, Mary Ann
AU - Roos, Bernard A
AU - Carver, Charles S
AU - Schneiderman, Neil
PY - 2006/4
Y1 - 2006/4
N2 - Objective: This study evaluated relations among optimism, depression, anger suppression and natural killer cell cytotoxicity (NKCC) in 61 men treated for localized prostate cancer (PC). Method: All participants were assessed at a single time point where demographics, optimism, depression and anger suppression were measured. We also collected peripheral venous blood to assess NKCC. Results: Results showed that greater optimism was associated with greater NKCC (β=.27, P<.05), less depression (β=-.63, P<.001) and less anger suppression (β=-.29, P<.05). Furthermore, less anger suppression (β=-.35, P<.01) was associated with greater NKCC. In a hierarchical regression model controlling for depression and then anger suppression, the relationship between optimism and NKCC became nonsignificant [β=.18, t(56)=1.51, P=.14], while anger suppression remained significantly correlated with NKCC [β=-.29, t(56)=-2.40, P<.05]. Conclusions: Results suggest that optimism is associated with NKCC and a greater ability to adaptively express anger. Furthermore, it appears that less anger suppression partially mediates the relationship between optimism and NKCC.
AB - Objective: This study evaluated relations among optimism, depression, anger suppression and natural killer cell cytotoxicity (NKCC) in 61 men treated for localized prostate cancer (PC). Method: All participants were assessed at a single time point where demographics, optimism, depression and anger suppression were measured. We also collected peripheral venous blood to assess NKCC. Results: Results showed that greater optimism was associated with greater NKCC (β=.27, P<.05), less depression (β=-.63, P<.001) and less anger suppression (β=-.29, P<.05). Furthermore, less anger suppression (β=-.35, P<.01) was associated with greater NKCC. In a hierarchical regression model controlling for depression and then anger suppression, the relationship between optimism and NKCC became nonsignificant [β=.18, t(56)=1.51, P=.14], while anger suppression remained significantly correlated with NKCC [β=-.29, t(56)=-2.40, P<.05]. Conclusions: Results suggest that optimism is associated with NKCC and a greater ability to adaptively express anger. Furthermore, it appears that less anger suppression partially mediates the relationship between optimism and NKCC.
KW - Anger suppression
KW - Depression
KW - Natural killer cell cytotoxicity
KW - Optimism
KW - Prostate cancer
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UR - http://www.scopus.com/inward/citedby.url?scp=33645850691&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychores.2005.08.001
DO - 10.1016/j.jpsychores.2005.08.001
M3 - Article
C2 - 16581368
AN - SCOPUS:33645850691
VL - 60
SP - 423
EP - 427
JO - Journal of Psychosomatic Research
JF - Journal of Psychosomatic Research
SN - 0022-3999
IS - 4
ER -
