Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer

Frank J. Penedo, Jason R. Dahn, Dave Kinsinger, Michael H Antoni, Ivan Molton, Jeffrey S. Gonzalez, Mary Anne Fletcher, Bernard Roos, Charles S Carver, Neil Schneiderman

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective: This study evaluated relations among optimism, depression, anger suppression and natural killer cell cytotoxicity (NKCC) in 61 men treated for localized prostate cancer (PC). Method: All participants were assessed at a single time point where demographics, optimism, depression and anger suppression were measured. We also collected peripheral venous blood to assess NKCC. Results: Results showed that greater optimism was associated with greater NKCC (β=.27, P<.05), less depression (β=-.63, P<.001) and less anger suppression (β=-.29, P<.05). Furthermore, less anger suppression (β=-.35, P<.01) was associated with greater NKCC. In a hierarchical regression model controlling for depression and then anger suppression, the relationship between optimism and NKCC became nonsignificant [β=.18, t(56)=1.51, P=.14], while anger suppression remained significantly correlated with NKCC [β=-.29, t(56)=-2.40, P<.05]. Conclusions: Results suggest that optimism is associated with NKCC and a greater ability to adaptively express anger. Furthermore, it appears that less anger suppression partially mediates the relationship between optimism and NKCC.

Original languageEnglish
Pages (from-to)423-427
Number of pages5
JournalJournal of Psychosomatic Research
Volume60
Issue number4
DOIs
StatePublished - Apr 1 2006

Fingerprint

Anger
Natural Killer Cells
Prostatic Neoplasms
Depression
Aptitude
Optimism
Demography

Keywords

  • Anger suppression
  • Depression
  • Natural killer cell cytotoxicity
  • Optimism
  • Prostate cancer

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer. / Penedo, Frank J.; Dahn, Jason R.; Kinsinger, Dave; Antoni, Michael H; Molton, Ivan; Gonzalez, Jeffrey S.; Fletcher, Mary Anne; Roos, Bernard; Carver, Charles S; Schneiderman, Neil.

In: Journal of Psychosomatic Research, Vol. 60, No. 4, 01.04.2006, p. 423-427.

Research output: Contribution to journalArticle

Penedo, Frank J. ; Dahn, Jason R. ; Kinsinger, Dave ; Antoni, Michael H ; Molton, Ivan ; Gonzalez, Jeffrey S. ; Fletcher, Mary Anne ; Roos, Bernard ; Carver, Charles S ; Schneiderman, Neil. / Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer. In: Journal of Psychosomatic Research. 2006 ; Vol. 60, No. 4. pp. 423-427.
@article{7f2a7436e3c643f88372169f3fe2fefd,
title = "Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer",
abstract = "Objective: This study evaluated relations among optimism, depression, anger suppression and natural killer cell cytotoxicity (NKCC) in 61 men treated for localized prostate cancer (PC). Method: All participants were assessed at a single time point where demographics, optimism, depression and anger suppression were measured. We also collected peripheral venous blood to assess NKCC. Results: Results showed that greater optimism was associated with greater NKCC (β=.27, P<.05), less depression (β=-.63, P<.001) and less anger suppression (β=-.29, P<.05). Furthermore, less anger suppression (β=-.35, P<.01) was associated with greater NKCC. In a hierarchical regression model controlling for depression and then anger suppression, the relationship between optimism and NKCC became nonsignificant [β=.18, t(56)=1.51, P=.14], while anger suppression remained significantly correlated with NKCC [β=-.29, t(56)=-2.40, P<.05]. Conclusions: Results suggest that optimism is associated with NKCC and a greater ability to adaptively express anger. Furthermore, it appears that less anger suppression partially mediates the relationship between optimism and NKCC.",
keywords = "Anger suppression, Depression, Natural killer cell cytotoxicity, Optimism, Prostate cancer",
author = "Penedo, {Frank J.} and Dahn, {Jason R.} and Dave Kinsinger and Antoni, {Michael H} and Ivan Molton and Gonzalez, {Jeffrey S.} and Fletcher, {Mary Anne} and Bernard Roos and Carver, {Charles S} and Neil Schneiderman",
year = "2006",
month = "4",
day = "1",
doi = "10.1016/j.jpsychores.2005.08.001",
language = "English",
volume = "60",
pages = "423--427",
journal = "Journal of Psychosomatic Research",
issn = "0022-3999",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Anger suppression mediates the relationship between optimism and natural killer cell cytotoxicity in men treated for localized prostate cancer

AU - Penedo, Frank J.

AU - Dahn, Jason R.

AU - Kinsinger, Dave

AU - Antoni, Michael H

AU - Molton, Ivan

AU - Gonzalez, Jeffrey S.

AU - Fletcher, Mary Anne

AU - Roos, Bernard

AU - Carver, Charles S

AU - Schneiderman, Neil

PY - 2006/4/1

Y1 - 2006/4/1

N2 - Objective: This study evaluated relations among optimism, depression, anger suppression and natural killer cell cytotoxicity (NKCC) in 61 men treated for localized prostate cancer (PC). Method: All participants were assessed at a single time point where demographics, optimism, depression and anger suppression were measured. We also collected peripheral venous blood to assess NKCC. Results: Results showed that greater optimism was associated with greater NKCC (β=.27, P<.05), less depression (β=-.63, P<.001) and less anger suppression (β=-.29, P<.05). Furthermore, less anger suppression (β=-.35, P<.01) was associated with greater NKCC. In a hierarchical regression model controlling for depression and then anger suppression, the relationship between optimism and NKCC became nonsignificant [β=.18, t(56)=1.51, P=.14], while anger suppression remained significantly correlated with NKCC [β=-.29, t(56)=-2.40, P<.05]. Conclusions: Results suggest that optimism is associated with NKCC and a greater ability to adaptively express anger. Furthermore, it appears that less anger suppression partially mediates the relationship between optimism and NKCC.

AB - Objective: This study evaluated relations among optimism, depression, anger suppression and natural killer cell cytotoxicity (NKCC) in 61 men treated for localized prostate cancer (PC). Method: All participants were assessed at a single time point where demographics, optimism, depression and anger suppression were measured. We also collected peripheral venous blood to assess NKCC. Results: Results showed that greater optimism was associated with greater NKCC (β=.27, P<.05), less depression (β=-.63, P<.001) and less anger suppression (β=-.29, P<.05). Furthermore, less anger suppression (β=-.35, P<.01) was associated with greater NKCC. In a hierarchical regression model controlling for depression and then anger suppression, the relationship between optimism and NKCC became nonsignificant [β=.18, t(56)=1.51, P=.14], while anger suppression remained significantly correlated with NKCC [β=-.29, t(56)=-2.40, P<.05]. Conclusions: Results suggest that optimism is associated with NKCC and a greater ability to adaptively express anger. Furthermore, it appears that less anger suppression partially mediates the relationship between optimism and NKCC.

KW - Anger suppression

KW - Depression

KW - Natural killer cell cytotoxicity

KW - Optimism

KW - Prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=33645850691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645850691&partnerID=8YFLogxK

U2 - 10.1016/j.jpsychores.2005.08.001

DO - 10.1016/j.jpsychores.2005.08.001

M3 - Article

C2 - 16581368

AN - SCOPUS:33645850691

VL - 60

SP - 423

EP - 427

JO - Journal of Psychosomatic Research

JF - Journal of Psychosomatic Research

SN - 0022-3999

IS - 4

ER -