Androgenic sex steroids contribute to metabolic risk beyond intra-abdominal fat in overweight/obese black and white women

Arlette Perry, Xuewen Wang, Ronald B Goldberg, Robert Ross, Loreto Jackson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective To determine the independent contribution of androgenic sex hormones beyond visceral adipose tissue (VAT) on metabolic risk. Design and Methods A cross-sectional evaluation of 66 (36 white and 30 black) premenopausal overweight/obese women using multiple regression analyses to determine the independent effects of sex hormone-binding globulin (SHBG), total testosterone (TT), and free testosterone using the free androgen index (FAI) on metabolic variables above VAT. Results SHBG contributed to the variance in insulin (P = 0.003), insulin resistance using HOMA-IR (P = 0.006), and high-density lipoprotein cholesterol2 (P = 0.029). TT contributed to the variance in systolic and diastolic blood pressure (P < 0.001), total cholesterol (P = 0.003), low-density lipoprotein cholesterol (P = 0.003), and apolipoprotein B (P = 0.004). FAI contributed to the variance in the greatest number of metabolic variables beyond VAT. There was also a significant race-FAI interaction for fasting glucose (P = 0.013). A Pearson's correlation coefficient showed a significant relationship between FAI and glucose in white women (r = 0.48, P = 0.003) while showing no relationship in black women (r = -0.01, P = 0.941). Conclusions Our study showed that androgenic sex steroids contributed significantly to the variance in metabolic variables associated with health risk. However, they do not provide sufficient information relevant to glucose status in black women.

Original languageEnglish
Pages (from-to)1618-1624
Number of pages7
JournalObesity
Volume21
Issue number8
DOIs
StatePublished - Aug 1 2013

Fingerprint

Intra-Abdominal Fat
Androgens
Steroids
Testosterone
Sex Hormone-Binding Globulin
Glucose
Blood Pressure
Apolipoproteins B
Gonadal Steroid Hormones
HDL Lipoproteins
LDL Cholesterol
Insulin Resistance
Fasting
Cholesterol
Regression Analysis
Insulin
hydroquinone
Health

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Androgenic sex steroids contribute to metabolic risk beyond intra-abdominal fat in overweight/obese black and white women. / Perry, Arlette; Wang, Xuewen; Goldberg, Ronald B; Ross, Robert; Jackson, Loreto.

In: Obesity, Vol. 21, No. 8, 01.08.2013, p. 1618-1624.

Research output: Contribution to journalArticle

@article{0cbf5b31d65447a2aa63a1ae69f19faf,
title = "Androgenic sex steroids contribute to metabolic risk beyond intra-abdominal fat in overweight/obese black and white women",
abstract = "Objective To determine the independent contribution of androgenic sex hormones beyond visceral adipose tissue (VAT) on metabolic risk. Design and Methods A cross-sectional evaluation of 66 (36 white and 30 black) premenopausal overweight/obese women using multiple regression analyses to determine the independent effects of sex hormone-binding globulin (SHBG), total testosterone (TT), and free testosterone using the free androgen index (FAI) on metabolic variables above VAT. Results SHBG contributed to the variance in insulin (P = 0.003), insulin resistance using HOMA-IR (P = 0.006), and high-density lipoprotein cholesterol2 (P = 0.029). TT contributed to the variance in systolic and diastolic blood pressure (P < 0.001), total cholesterol (P = 0.003), low-density lipoprotein cholesterol (P = 0.003), and apolipoprotein B (P = 0.004). FAI contributed to the variance in the greatest number of metabolic variables beyond VAT. There was also a significant race-FAI interaction for fasting glucose (P = 0.013). A Pearson's correlation coefficient showed a significant relationship between FAI and glucose in white women (r = 0.48, P = 0.003) while showing no relationship in black women (r = -0.01, P = 0.941). Conclusions Our study showed that androgenic sex steroids contributed significantly to the variance in metabolic variables associated with health risk. However, they do not provide sufficient information relevant to glucose status in black women.",
author = "Arlette Perry and Xuewen Wang and Goldberg, {Ronald B} and Robert Ross and Loreto Jackson",
year = "2013",
month = "8",
day = "1",
doi = "10.1002/oby.20204",
language = "English",
volume = "21",
pages = "1618--1624",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Androgenic sex steroids contribute to metabolic risk beyond intra-abdominal fat in overweight/obese black and white women

AU - Perry, Arlette

AU - Wang, Xuewen

AU - Goldberg, Ronald B

AU - Ross, Robert

AU - Jackson, Loreto

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Objective To determine the independent contribution of androgenic sex hormones beyond visceral adipose tissue (VAT) on metabolic risk. Design and Methods A cross-sectional evaluation of 66 (36 white and 30 black) premenopausal overweight/obese women using multiple regression analyses to determine the independent effects of sex hormone-binding globulin (SHBG), total testosterone (TT), and free testosterone using the free androgen index (FAI) on metabolic variables above VAT. Results SHBG contributed to the variance in insulin (P = 0.003), insulin resistance using HOMA-IR (P = 0.006), and high-density lipoprotein cholesterol2 (P = 0.029). TT contributed to the variance in systolic and diastolic blood pressure (P < 0.001), total cholesterol (P = 0.003), low-density lipoprotein cholesterol (P = 0.003), and apolipoprotein B (P = 0.004). FAI contributed to the variance in the greatest number of metabolic variables beyond VAT. There was also a significant race-FAI interaction for fasting glucose (P = 0.013). A Pearson's correlation coefficient showed a significant relationship between FAI and glucose in white women (r = 0.48, P = 0.003) while showing no relationship in black women (r = -0.01, P = 0.941). Conclusions Our study showed that androgenic sex steroids contributed significantly to the variance in metabolic variables associated with health risk. However, they do not provide sufficient information relevant to glucose status in black women.

AB - Objective To determine the independent contribution of androgenic sex hormones beyond visceral adipose tissue (VAT) on metabolic risk. Design and Methods A cross-sectional evaluation of 66 (36 white and 30 black) premenopausal overweight/obese women using multiple regression analyses to determine the independent effects of sex hormone-binding globulin (SHBG), total testosterone (TT), and free testosterone using the free androgen index (FAI) on metabolic variables above VAT. Results SHBG contributed to the variance in insulin (P = 0.003), insulin resistance using HOMA-IR (P = 0.006), and high-density lipoprotein cholesterol2 (P = 0.029). TT contributed to the variance in systolic and diastolic blood pressure (P < 0.001), total cholesterol (P = 0.003), low-density lipoprotein cholesterol (P = 0.003), and apolipoprotein B (P = 0.004). FAI contributed to the variance in the greatest number of metabolic variables beyond VAT. There was also a significant race-FAI interaction for fasting glucose (P = 0.013). A Pearson's correlation coefficient showed a significant relationship between FAI and glucose in white women (r = 0.48, P = 0.003) while showing no relationship in black women (r = -0.01, P = 0.941). Conclusions Our study showed that androgenic sex steroids contributed significantly to the variance in metabolic variables associated with health risk. However, they do not provide sufficient information relevant to glucose status in black women.

UR - http://www.scopus.com/inward/record.url?scp=84883175918&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883175918&partnerID=8YFLogxK

U2 - 10.1002/oby.20204

DO - 10.1002/oby.20204

M3 - Article

C2 - 23670917

AN - SCOPUS:84883175918

VL - 21

SP - 1618

EP - 1624

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 8

ER -