Androgen receptor antigen density and S-phase fraction in prostate cancer: A pilot study

M. Abdel-Wahab, Awtar K. Ganju-Krishan, C. Milikowski, A. A. Wahab, G. Walker, A. Markoe

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Purpose: To determine whether quantitative flow cytometric androgen receptor density expression (MFC ratio) in prostate cancer was associated with S-phase fraction. Methods: Flow cytometry was performed to determine DNA aneuploidy, S-phase fraction, percentage of androgen receptor (AR)-positive cells, and MFC ratio in prostate cancer patients. Results: MFC ratio showed distinct clustering. Eight patients had a low MFC ratio of 1.78-2.74, while 10 patients had high MFC ratios between 4.99 and 6.48. The S-phase fraction had average values of 11.05 vs 4.92 in tumors with high vs low MFC ratio (P<0.01). Conclusion: S-phase fraction was significantly higher in tumors with high AR density.

Original languageEnglish (US)
Pages (from-to)294-300
Number of pages7
JournalProstate Cancer and Prostatic Diseases
Volume6
Issue number4
DOIs
StatePublished - Dec 1 2003

Keywords

  • Androgen receptors
  • Antigen density
  • S-phase fraction

ASJC Scopus subject areas

  • Oncology
  • Urology

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