Androgen receptor antigen density and S-phase fraction in prostate cancer: A pilot study

M. Abdel-Wahab; A. Krishan; C. Milikowski; A. A. Wahab; G. Walker; A. Markoe

doi:10.1038/sj.pcan.4500672

Androgen receptor antigen density and S-phase fraction in prostate cancer: A pilot study

M. Abdel-Wahab, A. Krishan, C. Milikowski, A. A. Wahab, G. Walker, A. Markoe

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Purpose: To determine whether quantitative flow cytometric androgen receptor density expression (MFC ratio) in prostate cancer was associated with S-phase fraction. Methods: Flow cytometry was performed to determine DNA aneuploidy, S-phase fraction, percentage of androgen receptor (AR)-positive cells, and MFC ratio in prostate cancer patients. Results: MFC ratio showed distinct clustering. Eight patients had a low MFC ratio of 1.78-2.74, while 10 patients had high MFC ratios between 4.99 and 6.48. The S-phase fraction had average values of 11.05 vs 4.92 in tumors with high vs low MFC ratio (P<0.01). Conclusion: S-phase fraction was significantly higher in tumors with high AR density.

Original language	English (US)
Pages (from-to)	294-300
Number of pages	7
Journal	Prostate Cancer and Prostatic Diseases
Volume	6
Issue number	4
DOIs	https://doi.org/10.1038/sj.pcan.4500672
State	Published - 2003

Keywords

Androgen receptors
Antigen density
S-phase fraction

ASJC Scopus subject areas

Oncology
Urology

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10.1038/sj.pcan.4500672

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title = "Androgen receptor antigen density and S-phase fraction in prostate cancer: A pilot study",

abstract = "Purpose: To determine whether quantitative flow cytometric androgen receptor density expression (MFC ratio) in prostate cancer was associated with S-phase fraction. Methods: Flow cytometry was performed to determine DNA aneuploidy, S-phase fraction, percentage of androgen receptor (AR)-positive cells, and MFC ratio in prostate cancer patients. Results: MFC ratio showed distinct clustering. Eight patients had a low MFC ratio of 1.78-2.74, while 10 patients had high MFC ratios between 4.99 and 6.48. The S-phase fraction had average values of 11.05 vs 4.92 in tumors with high vs low MFC ratio (P<0.01). Conclusion: S-phase fraction was significantly higher in tumors with high AR density.",

keywords = "Androgen receptors, Antigen density, S-phase fraction",

author = "M. Abdel-Wahab and A. Krishan and C. Milikowski and Wahab, {A. A.} and G. Walker and A. Markoe",

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T1 - Androgen receptor antigen density and S-phase fraction in prostate cancer

T2 - A pilot study

AU - Abdel-Wahab, M.

AU - Krishan, A.

AU - Milikowski, C.

AU - Wahab, A. A.

AU - Walker, G.

AU - Markoe, A.

PY - 2003

Y1 - 2003

N2 - Purpose: To determine whether quantitative flow cytometric androgen receptor density expression (MFC ratio) in prostate cancer was associated with S-phase fraction. Methods: Flow cytometry was performed to determine DNA aneuploidy, S-phase fraction, percentage of androgen receptor (AR)-positive cells, and MFC ratio in prostate cancer patients. Results: MFC ratio showed distinct clustering. Eight patients had a low MFC ratio of 1.78-2.74, while 10 patients had high MFC ratios between 4.99 and 6.48. The S-phase fraction had average values of 11.05 vs 4.92 in tumors with high vs low MFC ratio (P<0.01). Conclusion: S-phase fraction was significantly higher in tumors with high AR density.

AB - Purpose: To determine whether quantitative flow cytometric androgen receptor density expression (MFC ratio) in prostate cancer was associated with S-phase fraction. Methods: Flow cytometry was performed to determine DNA aneuploidy, S-phase fraction, percentage of androgen receptor (AR)-positive cells, and MFC ratio in prostate cancer patients. Results: MFC ratio showed distinct clustering. Eight patients had a low MFC ratio of 1.78-2.74, while 10 patients had high MFC ratios between 4.99 and 6.48. The S-phase fraction had average values of 11.05 vs 4.92 in tumors with high vs low MFC ratio (P<0.01). Conclusion: S-phase fraction was significantly higher in tumors with high AR density.

KW - Androgen receptors

KW - Antigen density

KW - S-phase fraction

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