Androgen receptor antigen density and S-phase fraction in prostate cancer: A pilot study

M. Abdel-Wahab; Awtar K. Ganju-Krishan; C. Milikowski; A. A. Wahab; G. Walker; A. Markoe

doi:10.1038/sj.pcan.4500672

Androgen receptor antigen density and S-phase fraction in prostate cancer: A pilot study

M. Abdel-Wahab, Awtar K. Ganju-Krishan, C. Milikowski, A. A. Wahab, G. Walker, A. Markoe

Research output: Contribution to journal › Article

2 Scopus citations

Abstract

Purpose: To determine whether quantitative flow cytometric androgen receptor density expression (MFC ratio) in prostate cancer was associated with S-phase fraction. Methods: Flow cytometry was performed to determine DNA aneuploidy, S-phase fraction, percentage of androgen receptor (AR)-positive cells, and MFC ratio in prostate cancer patients. Results: MFC ratio showed distinct clustering. Eight patients had a low MFC ratio of 1.78-2.74, while 10 patients had high MFC ratios between 4.99 and 6.48. The S-phase fraction had average values of 11.05 vs 4.92 in tumors with high vs low MFC ratio (P<0.01). Conclusion: S-phase fraction was significantly higher in tumors with high AR density.

Original language	English (US)
Pages (from-to)	294-300
Number of pages	7
Journal	Prostate Cancer and Prostatic Diseases
Volume	6
Issue number	4
DOIs	https://doi.org/10.1038/sj.pcan.4500672
State	Published - Dec 1 2003

Keywords

Androgen receptors
Antigen density
S-phase fraction

ASJC Scopus subject areas

Oncology
Urology

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Abdel-Wahab, M., Ganju-Krishan, A. K., Milikowski, C., Wahab, A. A., Walker, G., & Markoe, A. (2003). Androgen receptor antigen density and S-phase fraction in prostate cancer: A pilot study. Prostate Cancer and Prostatic Diseases, 6(4), 294-300. https://doi.org/10.1038/sj.pcan.4500672

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abstract = "Purpose: To determine whether quantitative flow cytometric androgen receptor density expression (MFC ratio) in prostate cancer was associated with S-phase fraction. Methods: Flow cytometry was performed to determine DNA aneuploidy, S-phase fraction, percentage of androgen receptor (AR)-positive cells, and MFC ratio in prostate cancer patients. Results: MFC ratio showed distinct clustering. Eight patients had a low MFC ratio of 1.78-2.74, while 10 patients had high MFC ratios between 4.99 and 6.48. The S-phase fraction had average values of 11.05 vs 4.92 in tumors with high vs low MFC ratio (P<0.01). Conclusion: S-phase fraction was significantly higher in tumors with high AR density.",

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AU - Abdel-Wahab, M.

AU - Ganju-Krishan, Awtar K.

AU - Milikowski, C.

AU - Wahab, A. A.

AU - Walker, G.

AU - Markoe, A.

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