Abstract
Purpose: To determine whether quantitative flow cytometric androgen receptor density expression (MFC ratio) in prostate cancer was associated with S-phase fraction. Methods: Flow cytometry was performed to determine DNA aneuploidy, S-phase fraction, percentage of androgen receptor (AR)-positive cells, and MFC ratio in prostate cancer patients. Results: MFC ratio showed distinct clustering. Eight patients had a low MFC ratio of 1.78-2.74, while 10 patients had high MFC ratios between 4.99 and 6.48. The S-phase fraction had average values of 11.05 vs 4.92 in tumors with high vs low MFC ratio (P<0.01). Conclusion: S-phase fraction was significantly higher in tumors with high AR density.
Original language | English (US) |
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Pages (from-to) | 294-300 |
Number of pages | 7 |
Journal | Prostate Cancer and Prostatic Diseases |
Volume | 6 |
Issue number | 4 |
DOIs | |
State | Published - 2003 |
Keywords
- Androgen receptors
- Antigen density
- S-phase fraction
ASJC Scopus subject areas
- Oncology
- Urology