Abstract
Single cell recordings were made from neurons in the rostral medullary raphe (RMR) of the rabbit. The recording sites were ones that had been shown to yield pressor responses from electrical stimulation and by pressure injections of glutamate. Electrical stimulation of the intermediolateral (IML) region of the spinal cord led to antidromic activation of 12 of the 100 cells studied. Eleven of these cells were located in raphe pallidus or raphe magnus, and one cell was located in raphe obscurus. These findings were consistent with the results of horseradish peroxidase (HRP) histochemistry experiments. Injections of HRP into the IML led to heavy cell body labeling in raphe pallidus and raphe magnus, but sparse labeling in raphe obscurus. Cells in the RMR could be orthodromically activated by electrical stimulation of the putative defense area of the periaqueductal gray (PAG) but not by stimulation of putative defense areas in the hypothalamus. Most of these cells were located in raphe pallidus or raphe magnus. Similarly, HRP injections into raphe pallidus and raphe magnus led to heavy cell body labeling in the PAG but not the hypothalamus; no cell body labeling was found in the PAG when injections were made into raphe obscurus.
| Original language | English |
|---|---|
| Pages (from-to) | 176-182 |
| Number of pages | 7 |
| Journal | Brain Research |
| Volume | 453 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jun 21 1988 |
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Keywords
- Blood pressure
- Defense response
- Hypothalamus
- Intermediolateral horn
- Periaqueductal gray
- Raphe
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
Anatomical and functional connections of neurons of the rostral medullary raphe of the rabbit. / Haselton, James R.; Winters, Ray; Liskowsky, David R.; Haselton, Carole L.; McCabe, Philip; Schneiderman, Neil.
In: Brain Research, Vol. 453, No. 1-2, 21.06.1988, p. 176-182.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anatomical and functional connections of neurons of the rostral medullary raphe of the rabbit
AU - Haselton, James R.
AU - Winters, Ray
AU - Liskowsky, David R.
AU - Haselton, Carole L.
AU - McCabe, Philip
AU - Schneiderman, Neil
PY - 1988/6/21
Y1 - 1988/6/21
N2 - Single cell recordings were made from neurons in the rostral medullary raphe (RMR) of the rabbit. The recording sites were ones that had been shown to yield pressor responses from electrical stimulation and by pressure injections of glutamate. Electrical stimulation of the intermediolateral (IML) region of the spinal cord led to antidromic activation of 12 of the 100 cells studied. Eleven of these cells were located in raphe pallidus or raphe magnus, and one cell was located in raphe obscurus. These findings were consistent with the results of horseradish peroxidase (HRP) histochemistry experiments. Injections of HRP into the IML led to heavy cell body labeling in raphe pallidus and raphe magnus, but sparse labeling in raphe obscurus. Cells in the RMR could be orthodromically activated by electrical stimulation of the putative defense area of the periaqueductal gray (PAG) but not by stimulation of putative defense areas in the hypothalamus. Most of these cells were located in raphe pallidus or raphe magnus. Similarly, HRP injections into raphe pallidus and raphe magnus led to heavy cell body labeling in the PAG but not the hypothalamus; no cell body labeling was found in the PAG when injections were made into raphe obscurus.
AB - Single cell recordings were made from neurons in the rostral medullary raphe (RMR) of the rabbit. The recording sites were ones that had been shown to yield pressor responses from electrical stimulation and by pressure injections of glutamate. Electrical stimulation of the intermediolateral (IML) region of the spinal cord led to antidromic activation of 12 of the 100 cells studied. Eleven of these cells were located in raphe pallidus or raphe magnus, and one cell was located in raphe obscurus. These findings were consistent with the results of horseradish peroxidase (HRP) histochemistry experiments. Injections of HRP into the IML led to heavy cell body labeling in raphe pallidus and raphe magnus, but sparse labeling in raphe obscurus. Cells in the RMR could be orthodromically activated by electrical stimulation of the putative defense area of the periaqueductal gray (PAG) but not by stimulation of putative defense areas in the hypothalamus. Most of these cells were located in raphe pallidus or raphe magnus. Similarly, HRP injections into raphe pallidus and raphe magnus led to heavy cell body labeling in the PAG but not the hypothalamus; no cell body labeling was found in the PAG when injections were made into raphe obscurus.
KW - Blood pressure
KW - Defense response
KW - Hypothalamus
KW - Intermediolateral horn
KW - Periaqueductal gray
KW - Raphe
UR - http://www.scopus.com/inward/record.url?scp=0023929471&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023929471&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(88)90156-4
DO - 10.1016/0006-8993(88)90156-4
M3 - Article
VL - 453
SP - 176
EP - 182
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -