Anatomical and functional connections of neurons of the rostral medullary raphe of the rabbit

James R. Haselton, Ray Winters, David R. Liskowsky, Carole L. Haselton, Philip McCabe, Neil Schneiderman

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Single cell recordings were made from neurons in the rostral medullary raphe (RMR) of the rabbit. The recording sites were ones that had been shown to yield pressor responses from electrical stimulation and by pressure injections of glutamate. Electrical stimulation of the intermediolateral (IML) region of the spinal cord led to antidromic activation of 12 of the 100 cells studied. Eleven of these cells were located in raphe pallidus or raphe magnus, and one cell was located in raphe obscurus. These findings were consistent with the results of horseradish peroxidase (HRP) histochemistry experiments. Injections of HRP into the IML led to heavy cell body labeling in raphe pallidus and raphe magnus, but sparse labeling in raphe obscurus. Cells in the RMR could be orthodromically activated by electrical stimulation of the putative defense area of the periaqueductal gray (PAG) but not by stimulation of putative defense areas in the hypothalamus. Most of these cells were located in raphe pallidus or raphe magnus. Similarly, HRP injections into raphe pallidus and raphe magnus led to heavy cell body labeling in the PAG but not the hypothalamus; no cell body labeling was found in the PAG when injections were made into raphe obscurus.

Original languageEnglish
Pages (from-to)176-182
Number of pages7
JournalBrain Research
Volume453
Issue number1-2
DOIs
StatePublished - Jun 21 1988

Fingerprint

Rabbits
Neurons
Periaqueductal Gray
Horseradish Peroxidase
Electric Stimulation
Injections
Hypothalamus
Glutamic Acid
Spinal Cord
Pressure
Cell Body

Keywords

  • Blood pressure
  • Defense response
  • Hypothalamus
  • Intermediolateral horn
  • Periaqueductal gray
  • Raphe

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Anatomical and functional connections of neurons of the rostral medullary raphe of the rabbit. / Haselton, James R.; Winters, Ray; Liskowsky, David R.; Haselton, Carole L.; McCabe, Philip; Schneiderman, Neil.

In: Brain Research, Vol. 453, No. 1-2, 21.06.1988, p. 176-182.

Research output: Contribution to journalArticle

Haselton, James R. ; Winters, Ray ; Liskowsky, David R. ; Haselton, Carole L. ; McCabe, Philip ; Schneiderman, Neil. / Anatomical and functional connections of neurons of the rostral medullary raphe of the rabbit. In: Brain Research. 1988 ; Vol. 453, No. 1-2. pp. 176-182.
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