TY - JOUR
T1 - Anatomic localization of type 1 and type 2 macular neovascularization using swept-source OCT angiography
AU - Motulsky, Elie H.
AU - Zheng, Fang
AU - Shi, Yingying
AU - Gregori, Giovanni
AU - Rosenfeld, Philip J.
N1 - Funding Information:
Originally submitted May 25, 2018. Revision received August 20, 2018. Accepted for publication October 2, 2018. This study was supported by grants from Carl Zeiss Meditec (Dublin, CA); the Salah Foundation; an unrestricted grant from the Research to Prevent Blindness, New York, NY; and the National Eye Institute Center Core Grant (P30EY014801) to the Department of Ophthalmology, University of Miami Miller School of Medicine. Drs. Gregori and Rosenfeld received research support from Carl Zeiss Meditec. Dr. Gregori and the University of Miami co-own a patent that is licensed to Carl Zeiss Meditec. Dr. Rosenfeld received additional research support from Genentech and Tyrogenex; is a consultant for Achillion Pharmaceuticals, Acucela, Boehringer-Ingelheim, Carl Zeiss Meditec, Cell Cure Neurosciences, Chengdu Kanghong Biotech, Ocunexus Therapeutics, Genentech, Healios K.K, Hemera Biosciences, F. Hoffmann-La Roche Ltd., Isarna Pharmaceuticals, Lin Bioscience, MacRegen Inc., NGM Biopharmaceuticals, Ocunexus, Ocu-dyne, Tyrogenex, and Unity Biotechnology; and has equity interest in Apellis, Digisight, and Ocudyne. The remaining authors report no relevant financial disclosures. Address correspondence to Philip J. Rosenfeld, MD, PhD, Bascom Palmer Eye Institute, 900 NW 17th Street, Miami, FL 33136; email: prosenfeld@miami. edu. doi: 10.3928/23258160-20181101-09
PY - 2018/11
Y1 - 2018/11
N2 - BACKGROUND AND OBJECTIVE: Swept-source optical coherence tomography angiography (SS-OCTA) and different boundary-specific segmentation strategies were used to distinguish type 1 macular neovascularization (MNV) from type 2 MNV in eyes with exudative age-related macular degeneration (AMD). PATIENTS AND METHODS: Eyes with exudative AMD were enrolled in a prospective study. Segmentation strategies included a slab from the outer retina (OR) to the choriocapillaris (CC) for the entire MNV, a slab from the retinal pigment epithelium (RPE) to the CC for the type 1 MNV, and a slab from the OR to the RPE for the type 2 MNV. RESULTS: In 13 eyes, SS-OCTA B-scans and en face images using different segmentation strategies were able to identify type 1 and type 2 components of the MNV. CONCLUSION: In eyes with exudative AMD, SS-OCTA imaging and commercially available boundary-specific segmentation strategies were used to distinguish between type 1 and type 2 MNV.
AB - BACKGROUND AND OBJECTIVE: Swept-source optical coherence tomography angiography (SS-OCTA) and different boundary-specific segmentation strategies were used to distinguish type 1 macular neovascularization (MNV) from type 2 MNV in eyes with exudative age-related macular degeneration (AMD). PATIENTS AND METHODS: Eyes with exudative AMD were enrolled in a prospective study. Segmentation strategies included a slab from the outer retina (OR) to the choriocapillaris (CC) for the entire MNV, a slab from the retinal pigment epithelium (RPE) to the CC for the type 1 MNV, and a slab from the OR to the RPE for the type 2 MNV. RESULTS: In 13 eyes, SS-OCTA B-scans and en face images using different segmentation strategies were able to identify type 1 and type 2 components of the MNV. CONCLUSION: In eyes with exudative AMD, SS-OCTA imaging and commercially available boundary-specific segmentation strategies were used to distinguish between type 1 and type 2 MNV.
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U2 - 10.3928/23258160-20181101-09
DO - 10.3928/23258160-20181101-09
M3 - Article
C2 - 30457647
AN - SCOPUS:85056736789
VL - 49
SP - 878
EP - 886
JO - Ophthalmic Surgery Lasers and Imaging Retina
JF - Ophthalmic Surgery Lasers and Imaging Retina
SN - 2325-8160
IS - 11
ER -