Anastomosing hemangioma of the genitourinary system

Eight cases in the kidney and ovary with immunohistochemical and ultrastructural analysis

Oleksandr Kryvenko, Nilesh S. Gupta, Frederick A. Meier, Min W. Lee, Jonathan I. Epstein

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

We describe 3 ovarian and 5 renal anastomosing hemangiomas. One manifested with polycythemia, others were incidental; none recurred. The mean patient age was 58 years. Three hemangiomas developed in end-stage renal disease. Tumors were well-demarcated, mahogany brown, spongy lesions measuring 0.1 to 5 cm. Tortuous large vessels fed and drained tightly packed anastomosing sinusoidal capillary channels. Four hemangiomas exhibited lobular architecture, central edema/hyalinization, and intravascular growth. Five cases had thrombosis, hemorrhage, and hemosiderin. One ovarian tumor induced stromal luteinization. Three tumors had foci of extramedullary hematopoiesis (one associated with polycythemia). Six cases demonstrated eosinophilic intracytoplasmic globules. Three cases included hobnail endothelial cells. Atypia was minimal and mitoses were absent in all cases. We find this vascular neoplasm unique for the genitourinary system. Despite selected features mimicking angiosarcoma, our data support its benign nature. The current study expands the gross and radiographic appearance, clinical aspects, and ultrastructure, with the first report of the lesion occurring in the ovary.

Original languageEnglish (US)
Pages (from-to)450-457
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume136
Issue number3
DOIs
StatePublished - Sep 2011
Externally publishedYes

Fingerprint

Urogenital System
Hemangioma
Ovary
Polycythemia
Kidney
Vascular Neoplasms
Extramedullary Hematopoiesis
Luteinization
Hemosiderin
Neoplasms
Hemangiosarcoma
Mitosis
Chronic Kidney Failure
Edema
Thrombosis
Endothelial Cells
Hemorrhage
Growth

Keywords

  • Anastomosing hemangioma
  • Genitourinary
  • Hyaline globules
  • Intravascular

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Anastomosing hemangioma of the genitourinary system : Eight cases in the kidney and ovary with immunohistochemical and ultrastructural analysis. / Kryvenko, Oleksandr; Gupta, Nilesh S.; Meier, Frederick A.; Lee, Min W.; Epstein, Jonathan I.

In: American Journal of Clinical Pathology, Vol. 136, No. 3, 09.2011, p. 450-457.

Research output: Contribution to journalArticle

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