Anaplastic pleomorphic xanthoastrocytoma with spinal leptomeningeal spread at the time of diagnosis in an adult

Carolina Benjamin, Arline Faustin, Matija Snuderl, Donato Pacione

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We describe the first patient, to our knowledge, with anaplastic pleomorphic xanthoastrocytoma (PXA) with spinal leptomeningeal spread at the time of diagnosis and present a review of the literature. PXA is a tumor that typically has an indolent course but occasionally, when anaplastic features are present, behaves in a more aggressive manner. We found that PXA with spinal leptomeningeal spread at the time of diagnosis confers a worse prognosis. Craniospinal imaging should be obtained at time of diagnosis of PXA and the presence of leptomeningeal spread may be indicative of a more aggressive disease process.

Original languageEnglish (US)
Pages (from-to)1370-1373
Number of pages4
JournalJournal of Clinical Neuroscience
Volume22
Issue number8
DOIs
StatePublished - Aug 1 2015
Externally publishedYes

Keywords

  • Anaplastic
  • Craniospinal dissemination
  • Glioma
  • Leptomeningeal spread
  • Pleomorphic xanthoastrocytoma

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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