Anaphylactic reaction to platelet transfusion as the initial symptom of an undiagnosed systemic mastocytosis: a case report and review of the literature

Clifford R. Blieden, German Campuzano-Zuluaga, Adrienne Moul, Jennifer Chapman-Fredricks, Maureen Cioffi-Lavina, Offiong Ikpatt, Gerald E. Byrne, Francisco Vega

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: The association between anaphylactic reactions and systemic mastocytosis is well documented. However, platelet transfusion has not previously been reported as a potential elicitor of anaphylaxis in the context of systemic mastocytosis.

CASE PRESENTATION: We describe the clinicopathological findings of a 59-year-old Latin American man who presented to the emergency room with fatigue, leukocytosis, thrombocytopenia and mild hepatosplenomegaly. He developed two separate, temporally associated and severe anaphylactic reactions after receiving platelet transfusions. The result of a laboratory investigation for clerical errors and Coombs test was negative. Pre- and post-transfusion urine samples were negative for hemolysis. Bone marrow biopsy and aspirate smears performed demonstrated involvement by systemic mastocytosis, which had been previously undiagnosed.

CONCLUSIONS: We posit the transfusion reaction to be an anaphylactic reaction to transfused products as a result of heightened allergic sensitivity due to the underlying systemic mastocytosis. To the best of our knowledge, this is the first reported case of a severe anaphylactic-type reaction to blood products occurring in the setting of a previously undiagnosed systemic mastocytosis. Furthermore, it seems there are no published studies closely examining the relationship between hematopoietic neoplasms and transfusion reactions in general.

Original languageEnglish (US)
Pages (from-to)389
Number of pages1
JournalJournal of Medical Case Reports
Volume8
DOIs
StatePublished - 2014

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Systemic Mastocytosis
Platelet Transfusion
Anaphylaxis
Coombs Test
Leukocytosis
Hematologic Neoplasms
Hemolysis
Thrombocytopenia
Fatigue
Hospital Emergency Service
Bone Marrow
Urine
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Anaphylactic reaction to platelet transfusion as the initial symptom of an undiagnosed systemic mastocytosis : a case report and review of the literature. / Blieden, Clifford R.; Campuzano-Zuluaga, German; Moul, Adrienne; Chapman-Fredricks, Jennifer; Cioffi-Lavina, Maureen; Ikpatt, Offiong; Byrne, Gerald E.; Vega, Francisco.

In: Journal of Medical Case Reports, Vol. 8, 2014, p. 389.

Research output: Contribution to journalArticle

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