Analysis of the maternal components of the AIDS clinical trial group 076 zidovudine regimen in the prevention of mother-to-infant transmission of human immunodeficiency virus type 1

L. M. Frenkel, M. K. Cowles, D. E. Shapiro, A. J. Melvin, D. H. Watts, C. McLellan, K. Mohan, B. Murante, S. Burchett, Y. J. Bryson, M. J. O'Sullivan, C. Mitchell, D. Landers

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

To gain insight into the protective effects of the three components of the zidovudine regimen used in AIDS Clinical Trial Group (ACTG) 076 on mother-to-infant transmission of human immunodeficiency virus (HIV) type 1, 188 zidovudine-treated women and their untreated infants from five HIV-1 obstetric centers were retrospectively studied. The overall rate of mother- to-infant transmission was 12.3% (95% confidence interval [CI], 7.9%- 18.0%). When the 38 women with <200 CD4 cells/μL were excluded, the mother- to-infant transmission rate was 8.8% (95% CI, 4.6%-14.8%). This rate compares favorably with the 8.3% transmission in the zidovudine arm of the ACTG 076 study. Apart from low (<200/μL) maternal CD4 cells (P = .016), no factors, including the duration of zidovudine therapy during gestation and intravenous administration of zidovudine during labor, affected the rate of mother-to-infant transmission. These findings suggest that antenatal oral zidovudine may be as effective as antenatal oral plus intravenous zidovudine during labor and the three-component ACTG 076 regimen in decreasing mother- to-infant HIV-1 transmission.

Original languageEnglish (US)
Pages (from-to)971-974
Number of pages4
JournalJournal of Infectious Diseases
Volume175
Issue number4
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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