Abstract
Injecting drug use (IDU) is a major risk factor for contracting HIV-1 infection. Both HIV and IDU are neurotoxic, and their coexistence may lead to increased dysfunction of brain metabolic processes. The objective of this research was to investigate the effects of HIV-1 infection and IDU on 18F-FDG PET brain metabolism. Methods: 18F-FDG PET brain imaging, with a standard clinical protocol, was performed on 59 subjects who belonged to 3 groups: HIV-positive/IDU-positive (n = 17), HIV-negative/IDU- positive (n = 13), and HIV-negative/IDU-negative controls (n = 29). A voxel-based analysis of the 18F-FDG PET brain images was performed using statistical parametric mapping. The imageswere spatially normalized to a standard 18F-FDG template, proportionally scaled to compensate for count differences, and then appropriately smoothed. Statistical 2-sample t tests were performed to determine regional metabolic distribution differences in the 3 groups. Results: Diffuse hypermetabolism in the subcortical and deep white matter, the basal ganglia, and the thalami was observed in HIV-1 infection. IDU resulted in increased brainstem metabolism and decreased activity in cortical structures including bilateral medial frontal lobes and the right inferior frontal and temporal cortices. The cortical hypometabolism was more extensive in HIV-1-infected subjects, involving the left temporoparietal and right parietal cortices and bilateral medial frontal lobes. Conclusion: Voxel-based analysis of 18F-FDG PET brain images demonstrated statistically significant differences in regional metabolism for the 3 studied groups. It also showed that HIV-1 infection may have a synergistic effect with IDU, resulting in more extensive cortical hypometabolism. Correlation of these findings with other quantitative approaches and neurocognitive functioning is warranted.
| Original language | English |
|---|---|
| Pages (from-to) | 1999-2005 |
| Number of pages | 7 |
| Journal | Journal of Nuclear Medicine |
| Volume | 49 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2008 |
Fingerprint
Keywords
- F-FDG PET brain imaging
- HIV-1 infection
- Injecting drug use
- Statistical parametric mapping
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Analysis of the effects of injecting drug use and HIV-1 infection on 18F-FDG PET brain metabolism. / Georgiou, Mike; Gonenc, Ati; Waldrop-Valverde, Drenna; Kuker, Russ A.; Ezuddin, Shabbir; Sfakianakis, George N; Kumar, Mahendra.
In: Journal of Nuclear Medicine, Vol. 49, No. 12, 01.12.2008, p. 1999-2005.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of the effects of injecting drug use and HIV-1 infection on 18F-FDG PET brain metabolism
AU - Georgiou, Mike
AU - Gonenc, Ati
AU - Waldrop-Valverde, Drenna
AU - Kuker, Russ A.
AU - Ezuddin, Shabbir
AU - Sfakianakis, George N
AU - Kumar, Mahendra
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Injecting drug use (IDU) is a major risk factor for contracting HIV-1 infection. Both HIV and IDU are neurotoxic, and their coexistence may lead to increased dysfunction of brain metabolic processes. The objective of this research was to investigate the effects of HIV-1 infection and IDU on 18F-FDG PET brain metabolism. Methods: 18F-FDG PET brain imaging, with a standard clinical protocol, was performed on 59 subjects who belonged to 3 groups: HIV-positive/IDU-positive (n = 17), HIV-negative/IDU- positive (n = 13), and HIV-negative/IDU-negative controls (n = 29). A voxel-based analysis of the 18F-FDG PET brain images was performed using statistical parametric mapping. The imageswere spatially normalized to a standard 18F-FDG template, proportionally scaled to compensate for count differences, and then appropriately smoothed. Statistical 2-sample t tests were performed to determine regional metabolic distribution differences in the 3 groups. Results: Diffuse hypermetabolism in the subcortical and deep white matter, the basal ganglia, and the thalami was observed in HIV-1 infection. IDU resulted in increased brainstem metabolism and decreased activity in cortical structures including bilateral medial frontal lobes and the right inferior frontal and temporal cortices. The cortical hypometabolism was more extensive in HIV-1-infected subjects, involving the left temporoparietal and right parietal cortices and bilateral medial frontal lobes. Conclusion: Voxel-based analysis of 18F-FDG PET brain images demonstrated statistically significant differences in regional metabolism for the 3 studied groups. It also showed that HIV-1 infection may have a synergistic effect with IDU, resulting in more extensive cortical hypometabolism. Correlation of these findings with other quantitative approaches and neurocognitive functioning is warranted.
AB - Injecting drug use (IDU) is a major risk factor for contracting HIV-1 infection. Both HIV and IDU are neurotoxic, and their coexistence may lead to increased dysfunction of brain metabolic processes. The objective of this research was to investigate the effects of HIV-1 infection and IDU on 18F-FDG PET brain metabolism. Methods: 18F-FDG PET brain imaging, with a standard clinical protocol, was performed on 59 subjects who belonged to 3 groups: HIV-positive/IDU-positive (n = 17), HIV-negative/IDU- positive (n = 13), and HIV-negative/IDU-negative controls (n = 29). A voxel-based analysis of the 18F-FDG PET brain images was performed using statistical parametric mapping. The imageswere spatially normalized to a standard 18F-FDG template, proportionally scaled to compensate for count differences, and then appropriately smoothed. Statistical 2-sample t tests were performed to determine regional metabolic distribution differences in the 3 groups. Results: Diffuse hypermetabolism in the subcortical and deep white matter, the basal ganglia, and the thalami was observed in HIV-1 infection. IDU resulted in increased brainstem metabolism and decreased activity in cortical structures including bilateral medial frontal lobes and the right inferior frontal and temporal cortices. The cortical hypometabolism was more extensive in HIV-1-infected subjects, involving the left temporoparietal and right parietal cortices and bilateral medial frontal lobes. Conclusion: Voxel-based analysis of 18F-FDG PET brain images demonstrated statistically significant differences in regional metabolism for the 3 studied groups. It also showed that HIV-1 infection may have a synergistic effect with IDU, resulting in more extensive cortical hypometabolism. Correlation of these findings with other quantitative approaches and neurocognitive functioning is warranted.
KW - F-FDG PET brain imaging
KW - HIV-1 infection
KW - Injecting drug use
KW - Statistical parametric mapping
UR - http://www.scopus.com/inward/record.url?scp=57149118871&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57149118871&partnerID=8YFLogxK
U2 - 10.2967/jnumed.108.052688
DO - 10.2967/jnumed.108.052688
M3 - Article
C2 - 18997046
AN - SCOPUS:57149118871
VL - 49
SP - 1999
EP - 2005
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
SN - 0161-5505
IS - 12
ER -