Analysis of the dynamic permeation experiment with implication to cartilaginous tissue engineering

W. Y. Gu, D. N. Sun, W. M. Lai, V. C. Mow

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Abstract

In the present study, a I-D dynamic permeation of a monovalent electrolyte solution through a negatively charged-hydrated cartilaginous tissue is analyzed using the mechano-electrochemical theory developed by Lai et al. (1991) as the constitutive model for the tissue. The spatial distributions of stress, strain, fluid pressure, ion concentrations, electrical potential, ion and fluid fluxes within and across the tissue have been calculated. The dependencies of these mechanical, electrical and physicochemical responses on the tissue fixed charge density, with specified modulus, permeability, diffusion coefficients, and frequency and magnitude of pressure differential are determined. The results demonstrate that these mechanical, electrical and physicochemical fields within the tissue are intrinsically and nonlinearly coupled, and they all vary with time and depth within the tissue.

Original languageEnglish (US)
Pages (from-to)485-491
Number of pages7
JournalJournal of biomechanical engineering
Volume126
Issue number4
DOIs
StatePublished - Aug 1 2004

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ASJC Scopus subject areas

  • Biomedical Engineering
  • Physiology (medical)

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