Analysis of the correlation between local field potentials and neuronal firing rate in the motor cortex

Wang Yiwen, Justin C. Sanchez, Jose C. Principe, Jeremiah D. Mitzelfelt, Aysegul Gunduz

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Neuronal firing rate has been the signal of choice for invasive motor brain machine interfaces (BMI). The use of local field potentials (LFP) in BMI experiments may provide additional dendritic information about movement intent and may improve performance. Here we study the time-varying amplitude modulated relationship between local field potentials (LFP) and single unit activity (SUA) in the motor cortex. We record LFP and SUA in the primary motor cortex of rats trained to perform a lever pressing task, and evaluate the correlation between pairs of peri-event time histograms (PETH) and movement evoked local field potentials (mEP) at the same electrode. Three different correlation coefficients were calculated and compared between the neuronal PETH and the magnitude and power of the mEP. Correlation as high as 0.7 for some neurons occurred between the PETH and the mEP magnitude. As expected, the correlations between the single trial LFP and SUV are much lower due to the inherent variability of both signals.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages6185-6188
Number of pages4
DOIs
StatePublished - Dec 1 2006
Externally publishedYes
Event28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States
Duration: Aug 30 2006Sep 3 2006

Other

Other28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
CountryUnited States
CityNew York, NY
Period8/30/069/3/06

Fingerprint

Brain
Neurons
Rats
Electrodes
Experiments

ASJC Scopus subject areas

  • Bioengineering

Cite this

Yiwen, W., Sanchez, J. C., Principe, J. C., Mitzelfelt, J. D., & Gunduz, A. (2006). Analysis of the correlation between local field potentials and neuronal firing rate in the motor cortex. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (pp. 6185-6188). [4030125] https://doi.org/10.1109/IEMBS.2006.260516

Analysis of the correlation between local field potentials and neuronal firing rate in the motor cortex. / Yiwen, Wang; Sanchez, Justin C.; Principe, Jose C.; Mitzelfelt, Jeremiah D.; Gunduz, Aysegul.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. p. 6185-6188 4030125.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yiwen, W, Sanchez, JC, Principe, JC, Mitzelfelt, JD & Gunduz, A 2006, Analysis of the correlation between local field potentials and neuronal firing rate in the motor cortex. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings., 4030125, pp. 6185-6188, 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06, New York, NY, United States, 8/30/06. https://doi.org/10.1109/IEMBS.2006.260516
Yiwen W, Sanchez JC, Principe JC, Mitzelfelt JD, Gunduz A. Analysis of the correlation between local field potentials and neuronal firing rate in the motor cortex. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. p. 6185-6188. 4030125 https://doi.org/10.1109/IEMBS.2006.260516
Yiwen, Wang ; Sanchez, Justin C. ; Principe, Jose C. ; Mitzelfelt, Jeremiah D. ; Gunduz, Aysegul. / Analysis of the correlation between local field potentials and neuronal firing rate in the motor cortex. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2006. pp. 6185-6188
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