Abstract
Background: Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV. Objectives: To investigate Lp(a) expression in skin lesions and circulating serum Lp(a) levels in patients with LV. Methods: Skin biopsy samples from 38 patients (27 women and 11 men) with active lesions diagnosed as LV and 9 samples of normal skin (5 women and 4 men) from control patients without LV were evaluated for skin expression of Lp(a) by immunohistochemistry. Plasma levels of Lp(a) were analyzed by immunoturbidimetry. Results: We found that lesional skin in patients with LV expressed 10-fold higher Lp(a) immunostaining than controls. High plasma levels of Lp(a) were observed in LV patients. We did not find a correlation (P=.02) between expression of Lp(a) in the skin and plasma levels of Lp(a) in patients with LV. Conclusions: Increased Lp(a) expression in lesional skin of LV patients suggests the role of Lp(a) in the thrombo-occlusive vasculopathy observed in this disease.
| Original language | English (US) |
|---|---|
| Journal | Journal of Cutaneous Pathology |
| DOIs | |
| State | Accepted/In press - 2017 |
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Keywords
- Immunohistochemistry
- Leg ulcers
- Lipoprotein (a)
- Livedoid vasculopathy
- Thrombophilia
- Thrombosis
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
- Dermatology
Cite this
Analysis of serum levels and cutaneous expression of Lipoprotein (a) in 38 patients with livedoid vasculopathy. / Espinel, Danielle P.G.S.; Di Giacomo, Thais B.; Pincelli, Thais P.; Pereira, Naiura V.; Sotto, Miriam N.; Kirsner, Robert; Criado, Paulo R.
In: Journal of Cutaneous Pathology, 2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of serum levels and cutaneous expression of Lipoprotein (a) in 38 patients with livedoid vasculopathy
AU - Espinel, Danielle P.G.S.
AU - Di Giacomo, Thais B.
AU - Pincelli, Thais P.
AU - Pereira, Naiura V.
AU - Sotto, Miriam N.
AU - Kirsner, Robert
AU - Criado, Paulo R.
PY - 2017
Y1 - 2017
N2 - Background: Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV. Objectives: To investigate Lp(a) expression in skin lesions and circulating serum Lp(a) levels in patients with LV. Methods: Skin biopsy samples from 38 patients (27 women and 11 men) with active lesions diagnosed as LV and 9 samples of normal skin (5 women and 4 men) from control patients without LV were evaluated for skin expression of Lp(a) by immunohistochemistry. Plasma levels of Lp(a) were analyzed by immunoturbidimetry. Results: We found that lesional skin in patients with LV expressed 10-fold higher Lp(a) immunostaining than controls. High plasma levels of Lp(a) were observed in LV patients. We did not find a correlation (P=.02) between expression of Lp(a) in the skin and plasma levels of Lp(a) in patients with LV. Conclusions: Increased Lp(a) expression in lesional skin of LV patients suggests the role of Lp(a) in the thrombo-occlusive vasculopathy observed in this disease.
AB - Background: Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV. Objectives: To investigate Lp(a) expression in skin lesions and circulating serum Lp(a) levels in patients with LV. Methods: Skin biopsy samples from 38 patients (27 women and 11 men) with active lesions diagnosed as LV and 9 samples of normal skin (5 women and 4 men) from control patients without LV were evaluated for skin expression of Lp(a) by immunohistochemistry. Plasma levels of Lp(a) were analyzed by immunoturbidimetry. Results: We found that lesional skin in patients with LV expressed 10-fold higher Lp(a) immunostaining than controls. High plasma levels of Lp(a) were observed in LV patients. We did not find a correlation (P=.02) between expression of Lp(a) in the skin and plasma levels of Lp(a) in patients with LV. Conclusions: Increased Lp(a) expression in lesional skin of LV patients suggests the role of Lp(a) in the thrombo-occlusive vasculopathy observed in this disease.
KW - Immunohistochemistry
KW - Leg ulcers
KW - Lipoprotein (a)
KW - Livedoid vasculopathy
KW - Thrombophilia
KW - Thrombosis
UR - http://www.scopus.com/inward/record.url?scp=85031316425&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85031316425&partnerID=8YFLogxK
U2 - 10.1111/cup.13043
DO - 10.1111/cup.13043
M3 - Article
C2 - 28901563
AN - SCOPUS:85031316425
JO - Journal of Cutaneous Pathology
JF - Journal of Cutaneous Pathology
SN - 0303-6987
ER -