Analysis of serum levels and cutaneous expression of Lipoprotein (a) in 38 patients with livedoid vasculopathy

Danielle P.G.S. Espinel; Thais B. Di Giacomo; Thais P. Pincelli; Naiura V. Pereira; Miriam N. Sotto; Robert Kirsner; Paulo R. Criado

doi:10.1111/cup.13043

Analysis of serum levels and cutaneous expression of Lipoprotein (a) in 38 patients with livedoid vasculopathy

Danielle P.G.S. Espinel, Thais B. Di Giacomo, Thais P. Pincelli, Naiura V. Pereira, Miriam N. Sotto, Robert Kirsner, Paulo R. Criado

Dermatology & Cutaneous Surgery

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

Background: Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV. Objectives: To investigate Lp(a) expression in skin lesions and circulating serum Lp(a) levels in patients with LV. Methods: Skin biopsy samples from 38 patients (27 women and 11 men) with active lesions diagnosed as LV and 9 samples of normal skin (5 women and 4 men) from control patients without LV were evaluated for skin expression of Lp(a) by immunohistochemistry. Plasma levels of Lp(a) were analyzed by immunoturbidimetry. Results: We found that lesional skin in patients with LV expressed 10-fold higher Lp(a) immunostaining than controls. High plasma levels of Lp(a) were observed in LV patients. We did not find a correlation (P=.02) between expression of Lp(a) in the skin and plasma levels of Lp(a) in patients with LV. Conclusions: Increased Lp(a) expression in lesional skin of LV patients suggests the role of Lp(a) in the thrombo-occlusive vasculopathy observed in this disease.

Original language	English (US)
Journal	Journal of Cutaneous Pathology
DOIs	https://doi.org/10.1111/cup.13043
State	Accepted/In press - 2017

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Keywords

Immunohistochemistry
Leg ulcers
Lipoprotein (a)
Livedoid vasculopathy
Thrombophilia
Thrombosis

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology
Dermatology

Cite this

Espinel, D. P. G. S., Di Giacomo, T. B., Pincelli, T. P., Pereira, N. V., Sotto, M. N., Kirsner, R., & Criado, P. R. (Accepted/In press). Analysis of serum levels and cutaneous expression of Lipoprotein (a) in 38 patients with livedoid vasculopathy. Journal of Cutaneous Pathology. https://doi.org/10.1111/cup.13043

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title = "Analysis of serum levels and cutaneous expression of Lipoprotein (a) in 38 patients with livedoid vasculopathy",

abstract = "Background: Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV. Objectives: To investigate Lp(a) expression in skin lesions and circulating serum Lp(a) levels in patients with LV. Methods: Skin biopsy samples from 38 patients (27 women and 11 men) with active lesions diagnosed as LV and 9 samples of normal skin (5 women and 4 men) from control patients without LV were evaluated for skin expression of Lp(a) by immunohistochemistry. Plasma levels of Lp(a) were analyzed by immunoturbidimetry. Results: We found that lesional skin in patients with LV expressed 10-fold higher Lp(a) immunostaining than controls. High plasma levels of Lp(a) were observed in LV patients. We did not find a correlation (P=.02) between expression of Lp(a) in the skin and plasma levels of Lp(a) in patients with LV. Conclusions: Increased Lp(a) expression in lesional skin of LV patients suggests the role of Lp(a) in the thrombo-occlusive vasculopathy observed in this disease.",

keywords = "Immunohistochemistry, Leg ulcers, Lipoprotein (a), Livedoid vasculopathy, Thrombophilia, Thrombosis",

author = "Espinel, {Danielle P.G.S.} and {Di Giacomo}, {Thais B.} and Pincelli, {Thais P.} and Pereira, {Naiura V.} and Sotto, {Miriam N.} and Robert Kirsner and Criado, {Paulo R.}",

year = "2017",

doi = "10.1111/cup.13043",

language = "English (US)",

journal = "Journal of Cutaneous Pathology",

issn = "0303-6987",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Analysis of serum levels and cutaneous expression of Lipoprotein (a) in 38 patients with livedoid vasculopathy

AU - Espinel, Danielle P.G.S.

AU - Di Giacomo, Thais B.

AU - Pincelli, Thais P.

AU - Pereira, Naiura V.

AU - Sotto, Miriam N.

AU - Kirsner, Robert

AU - Criado, Paulo R.

PY - 2017

Y1 - 2017

N2 - Background: Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV. Objectives: To investigate Lp(a) expression in skin lesions and circulating serum Lp(a) levels in patients with LV. Methods: Skin biopsy samples from 38 patients (27 women and 11 men) with active lesions diagnosed as LV and 9 samples of normal skin (5 women and 4 men) from control patients without LV were evaluated for skin expression of Lp(a) by immunohistochemistry. Plasma levels of Lp(a) were analyzed by immunoturbidimetry. Results: We found that lesional skin in patients with LV expressed 10-fold higher Lp(a) immunostaining than controls. High plasma levels of Lp(a) were observed in LV patients. We did not find a correlation (P=.02) between expression of Lp(a) in the skin and plasma levels of Lp(a) in patients with LV. Conclusions: Increased Lp(a) expression in lesional skin of LV patients suggests the role of Lp(a) in the thrombo-occlusive vasculopathy observed in this disease.

AB - Background: Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV. Objectives: To investigate Lp(a) expression in skin lesions and circulating serum Lp(a) levels in patients with LV. Methods: Skin biopsy samples from 38 patients (27 women and 11 men) with active lesions diagnosed as LV and 9 samples of normal skin (5 women and 4 men) from control patients without LV were evaluated for skin expression of Lp(a) by immunohistochemistry. Plasma levels of Lp(a) were analyzed by immunoturbidimetry. Results: We found that lesional skin in patients with LV expressed 10-fold higher Lp(a) immunostaining than controls. High plasma levels of Lp(a) were observed in LV patients. We did not find a correlation (P=.02) between expression of Lp(a) in the skin and plasma levels of Lp(a) in patients with LV. Conclusions: Increased Lp(a) expression in lesional skin of LV patients suggests the role of Lp(a) in the thrombo-occlusive vasculopathy observed in this disease.

KW - Immunohistochemistry

KW - Leg ulcers

KW - Lipoprotein (a)

KW - Livedoid vasculopathy

KW - Thrombophilia

KW - Thrombosis

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DO - 10.1111/cup.13043

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10.1111/cup.13043