Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy

Danielle P.G.S. Espinel; Thais B. Di Giacomo; Thais P. Pincelli; Naiura V. Pereira; Miriam N. Sotto; Robert S. Kirsner; Paulo R. Criado

doi:10.1111/cup.13043

Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy

Danielle P.G.S. Espinel, Thais B. Di Giacomo, Thais P. Pincelli, Naiura V. Pereira, Miriam N. Sotto, Robert S. Kirsner, Paulo R. Criado

Dermatology & Cutaneous Surgery

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background: Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV. Objectives: To investigate Lp(a) expression in skin lesions and circulating serum Lp(a) levels in patients with LV. Methods: Skin biopsy samples from 38 patients (27 women and 11 men) with active lesions diagnosed as LV and 9 samples of normal skin (5 women and 4 men) from control patients without LV were evaluated for skin expression of Lp(a) by immunohistochemistry. Plasma levels of Lp(a) were analyzed by immunoturbidimetry. Results: We found that lesional skin in patients with LV expressed 10-fold higher Lp(a) immunostaining than controls. High plasma levels of Lp(a) were observed in LV patients. We did not find a correlation (P =.02) between expression of Lp(a) in the skin and plasma levels of Lp(a) in patients with LV. Conclusions: Increased Lp(a) expression in lesional skin of LV patients suggests the role of Lp(a) in the thrombo-occlusive vasculopathy observed in this disease.

Original language	English (US)
Pages (from-to)	1033-1037
Number of pages	5
Journal	Journal of Cutaneous Pathology
Volume	44
Issue number	12
DOIs	https://doi.org/10.1111/cup.13043
State	Published - Dec 2017

Keywords

immunohistochemistry
leg ulcers
lipoprotein (a)
livedoid vasculopathy
thrombophilia
thrombosis

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology
Dermatology

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Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy. / Espinel, Danielle P.G.S.; Di Giacomo, Thais B.; Pincelli, Thais P.; Pereira, Naiura V.; Sotto, Miriam N.; Kirsner, Robert S.; Criado, Paulo R.

In: Journal of Cutaneous Pathology, Vol. 44, No. 12, 12.2017, p. 1033-1037.

Research output: Contribution to journal › Article › peer-review

@article{267e081fea464a84bd2e470f46bc661e,

title = "Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy",

abstract = "Background: Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV. Objectives: To investigate Lp(a) expression in skin lesions and circulating serum Lp(a) levels in patients with LV. Methods: Skin biopsy samples from 38 patients (27 women and 11 men) with active lesions diagnosed as LV and 9 samples of normal skin (5 women and 4 men) from control patients without LV were evaluated for skin expression of Lp(a) by immunohistochemistry. Plasma levels of Lp(a) were analyzed by immunoturbidimetry. Results: We found that lesional skin in patients with LV expressed 10-fold higher Lp(a) immunostaining than controls. High plasma levels of Lp(a) were observed in LV patients. We did not find a correlation (P =.02) between expression of Lp(a) in the skin and plasma levels of Lp(a) in patients with LV. Conclusions: Increased Lp(a) expression in lesional skin of LV patients suggests the role of Lp(a) in the thrombo-occlusive vasculopathy observed in this disease.",

keywords = "immunohistochemistry, leg ulcers, lipoprotein (a), livedoid vasculopathy, thrombophilia, thrombosis",

author = "Espinel, {Danielle P.G.S.} and {Di Giacomo}, {Thais B.} and Pincelli, {Thais P.} and Pereira, {Naiura V.} and Sotto, {Miriam N.} and Kirsner, {Robert S.} and Criado, {Paulo R.}",

note = "Funding Information: This work was supported by Department of Dermatology, Hospital das Publisher Copyright: {\textcopyright} 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2017",

month = dec,

doi = "10.1111/cup.13043",

language = "English (US)",

volume = "44",

pages = "1033--1037",

journal = "Journal of Cutaneous Pathology",

issn = "0303-6987",

publisher = "Wiley-Blackwell",

number = "12",

}

TY - JOUR

T1 - Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy

AU - Espinel, Danielle P.G.S.

AU - Di Giacomo, Thais B.

AU - Pincelli, Thais P.

AU - Pereira, Naiura V.

AU - Sotto, Miriam N.

AU - Kirsner, Robert S.

AU - Criado, Paulo R.

N1 - Funding Information: This work was supported by Department of Dermatology, Hospital das Publisher Copyright: © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2017/12

Y1 - 2017/12

N2 - Background: Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV. Objectives: To investigate Lp(a) expression in skin lesions and circulating serum Lp(a) levels in patients with LV. Methods: Skin biopsy samples from 38 patients (27 women and 11 men) with active lesions diagnosed as LV and 9 samples of normal skin (5 women and 4 men) from control patients without LV were evaluated for skin expression of Lp(a) by immunohistochemistry. Plasma levels of Lp(a) were analyzed by immunoturbidimetry. Results: We found that lesional skin in patients with LV expressed 10-fold higher Lp(a) immunostaining than controls. High plasma levels of Lp(a) were observed in LV patients. We did not find a correlation (P =.02) between expression of Lp(a) in the skin and plasma levels of Lp(a) in patients with LV. Conclusions: Increased Lp(a) expression in lesional skin of LV patients suggests the role of Lp(a) in the thrombo-occlusive vasculopathy observed in this disease.

AB - Background: Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV. Objectives: To investigate Lp(a) expression in skin lesions and circulating serum Lp(a) levels in patients with LV. Methods: Skin biopsy samples from 38 patients (27 women and 11 men) with active lesions diagnosed as LV and 9 samples of normal skin (5 women and 4 men) from control patients without LV were evaluated for skin expression of Lp(a) by immunohistochemistry. Plasma levels of Lp(a) were analyzed by immunoturbidimetry. Results: We found that lesional skin in patients with LV expressed 10-fold higher Lp(a) immunostaining than controls. High plasma levels of Lp(a) were observed in LV patients. We did not find a correlation (P =.02) between expression of Lp(a) in the skin and plasma levels of Lp(a) in patients with LV. Conclusions: Increased Lp(a) expression in lesional skin of LV patients suggests the role of Lp(a) in the thrombo-occlusive vasculopathy observed in this disease.

KW - immunohistochemistry

KW - leg ulcers

KW - lipoprotein (a)

KW - livedoid vasculopathy

KW - thrombophilia

KW - thrombosis

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U2 - 10.1111/cup.13043

DO - 10.1111/cup.13043

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VL - 44

SP - 1033

EP - 1037

JO - Journal of Cutaneous Pathology

JF - Journal of Cutaneous Pathology

SN - 0303-6987

IS - 12

ER -

Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy

Abstract

Keywords

ASJC Scopus subject areas

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