Analysis of Huntington Disease linkage and age-of-onset distributions

C. Haynes, Margaret A Pericak-Vance, D. Dawson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Our analysis of the Huntington disease (HD) data set compares four different approaches for dealing with age of onset in HD and their effect on the resulting lod scores and estimates of the recombination fraction. The methods are: estimation of the age of onset curve by the normal distribution using sample mean and variance for ages of onset from affected family members, normal approximation using maximum likelihood which includes information on at-risk individuals, an exponential-type distribution based upon published data, and no adjustment for age of onset - dichotomy assumed.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalGenetic Epidemiology
Volume3
Issue numberSUPPL. 1
StatePublished - Dec 1 1986
Externally publishedYes

Fingerprint

Huntington Disease
Age Distribution
Age of Onset
Lod Score
Normal Distribution
Genetic Recombination
Research Design

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)
  • Medicine(all)

Cite this

Analysis of Huntington Disease linkage and age-of-onset distributions. / Haynes, C.; Pericak-Vance, Margaret A; Dawson, D.

In: Genetic Epidemiology, Vol. 3, No. SUPPL. 1, 01.12.1986, p. 235-239.

Research output: Contribution to journalArticle

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