Analysis of HLA DQα allele and genotype frequencies in populations from Florida

C. A. Crouse, W. J. Feuer, D. C. Nippes, S. C. Hutto, K. S. Barnes, D. Coffman, S. H. Livingston, L. Ginsberg, D. E. Glidewell

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

HLA DQα allele and genotype frequencies for Caucasian, African American, Haitian, and Hispanic populations in Florida have been estimated. The Florida laboratories involved in these studies collected donor samples from a variety of sites including clinical laboratories, victim and suspect standards, blood banks, county jail detainees, and laboratory personnel. We have determined that the Caucasian and African American DQα genotype frequencies do not deviate significantly from Hardy-Weinberg expectations and as a result of this heterogeneity analyses, data from the four Florida Caucasian populations may be combined and data from the four Florida African American populations may be combined to form two large HLA DQα genotype frequency databanks. Further, data from the Florida Haitian population may be combined with the Florida African American population. Comparison of the combined Florida Caucasian populations, combined Florida African American populations, the Palm Beach Sheriff's Office (PBSO) Hispanic, and PBSO Haitian population with other databases does not support combination because allele frequency distributions are heterogenous.

Original languageEnglish (US)
Pages (from-to)731-742
Number of pages12
JournalJournal of Forensic Sciences
Volume39
Issue number3
StatePublished - Dec 1 1994

Keywords

  • HLA DQα
  • allele
  • genotype frequencies
  • pathology and biology
  • population databanks

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Genetics

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    Crouse, C. A., Feuer, W. J., Nippes, D. C., Hutto, S. C., Barnes, K. S., Coffman, D., Livingston, S. H., Ginsberg, L., & Glidewell, D. E. (1994). Analysis of HLA DQα allele and genotype frequencies in populations from Florida. Journal of Forensic Sciences, 39(3), 731-742.