Analysis of HLA DQα allele and genotype frequencies in populations from Florida

C. A. Crouse, William J Feuer, D. C. Nippes, S. C. Hutto, K. S. Barnes, D. Coffman, S. H. Livingston, L. Ginsberg, D. E. Glidewell

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

HLA DQα allele and genotype frequencies for Caucasian, African American, Haitian, and Hispanic populations in Florida have been estimated. The Florida laboratories involved in these studies collected donor samples from a variety of sites including clinical laboratories, victim and suspect standards, blood banks, county jail detainees, and laboratory personnel. We have determined that the Caucasian and African American DQα genotype frequencies do not deviate significantly from Hardy-Weinberg expectations and as a result of this heterogeneity analyses, data from the four Florida Caucasian populations may be combined and data from the four Florida African American populations may be combined to form two large HLA DQα genotype frequency databanks. Further, data from the Florida Haitian population may be combined with the Florida African American population. Comparison of the combined Florida Caucasian populations, combined Florida African American populations, the Palm Beach Sheriff's Office (PBSO) Hispanic, and PBSO Haitian population with other databases does not support combination because allele frequency distributions are heterogenous.

Original languageEnglish (US)
Pages (from-to)731-742
Number of pages12
JournalJournal of Forensic Sciences
Volume39
Issue number3
StatePublished - 1994
Externally publishedYes

Fingerprint

HLA-DQ Antigens
Gene Frequency
Genotype
African Americans
Caucasian
Population
Hispanic Americans
Databases
Laboratory Personnel
Blood Banks
frequency distribution
personnel
bank
American
Tissue Donors

Keywords

  • allele
  • genotype frequencies
  • HLA DQα
  • pathology and biology
  • population databanks

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Law

Cite this

Crouse, C. A., Feuer, W. J., Nippes, D. C., Hutto, S. C., Barnes, K. S., Coffman, D., ... Glidewell, D. E. (1994). Analysis of HLA DQα allele and genotype frequencies in populations from Florida. Journal of Forensic Sciences, 39(3), 731-742.

Analysis of HLA DQα allele and genotype frequencies in populations from Florida. / Crouse, C. A.; Feuer, William J; Nippes, D. C.; Hutto, S. C.; Barnes, K. S.; Coffman, D.; Livingston, S. H.; Ginsberg, L.; Glidewell, D. E.

In: Journal of Forensic Sciences, Vol. 39, No. 3, 1994, p. 731-742.

Research output: Contribution to journalArticle

Crouse, CA, Feuer, WJ, Nippes, DC, Hutto, SC, Barnes, KS, Coffman, D, Livingston, SH, Ginsberg, L & Glidewell, DE 1994, 'Analysis of HLA DQα allele and genotype frequencies in populations from Florida', Journal of Forensic Sciences, vol. 39, no. 3, pp. 731-742.
Crouse CA, Feuer WJ, Nippes DC, Hutto SC, Barnes KS, Coffman D et al. Analysis of HLA DQα allele and genotype frequencies in populations from Florida. Journal of Forensic Sciences. 1994;39(3):731-742.
Crouse, C. A. ; Feuer, William J ; Nippes, D. C. ; Hutto, S. C. ; Barnes, K. S. ; Coffman, D. ; Livingston, S. H. ; Ginsberg, L. ; Glidewell, D. E. / Analysis of HLA DQα allele and genotype frequencies in populations from Florida. In: Journal of Forensic Sciences. 1994 ; Vol. 39, No. 3. pp. 731-742.
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