Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K)

Janet M. Grubber, Ann M. Saunders, Alison R. Crane-Gatherum, William K Scott, Eden R Martin, Carol S. Haynes, P. M. Conneally, Gary W. Small, Allen D. Roses, Jonathan L. Haines, Margaret A Pericak-Vance

Research output: Contribution to journalArticle

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Abstract

Butyrylcholinesterase (BCHE) is an enzyme expressed in most human tissues. Recently, an increased odds of carrying the K variant of BCHE (BCHE-K) was reported among Alzheimer disease (AD) cases as compared with controls. We tested our data set of 245 sporadic AD cases and 241 controls for an association between BCHE-K, APOE4, and AD using logistic regression and chi-square analyses. The sib transmission disequilibrium test (S-TDT) was also used to test for differences in BCHE-K allele frequencies between 163 discordant sib-pairs selected from multiplex AD families. No statistically significant differences were noted between BCHE-K case and control allele frequencies even after stratifying by APOE4 status. S-TDT analysis between the BCHE-K variant and AD was also not significant (P = 0.52). We conclude that BCHE-K is not a major genetic risk factor for AD in our study population.

Original languageEnglish
Pages (from-to)115-119
Number of pages5
JournalNeuroscience Letters
Volume269
Issue number2
DOIs
StatePublished - Jul 9 1999
Externally publishedYes

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Butyrylcholinesterase
Alzheimer Disease
Gene Frequency
Logistic Models

Keywords

  • Alzheimer disease
  • Apolipoprotein E
  • Association
  • Butyrylcholinesterase gene
  • Linkage disequilibrium
  • Transmission disequilibrium test

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K). / Grubber, Janet M.; Saunders, Ann M.; Crane-Gatherum, Alison R.; Scott, William K; Martin, Eden R; Haynes, Carol S.; Conneally, P. M.; Small, Gary W.; Roses, Allen D.; Haines, Jonathan L.; Pericak-Vance, Margaret A.

In: Neuroscience Letters, Vol. 269, No. 2, 09.07.1999, p. 115-119.

Research output: Contribution to journalArticle

Grubber, JM, Saunders, AM, Crane-Gatherum, AR, Scott, WK, Martin, ER, Haynes, CS, Conneally, PM, Small, GW, Roses, AD, Haines, JL & Pericak-Vance, MA 1999, 'Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K)', Neuroscience Letters, vol. 269, no. 2, pp. 115-119. https://doi.org/10.1016/S0304-3940(99)00426-7
Grubber, Janet M. ; Saunders, Ann M. ; Crane-Gatherum, Alison R. ; Scott, William K ; Martin, Eden R ; Haynes, Carol S. ; Conneally, P. M. ; Small, Gary W. ; Roses, Allen D. ; Haines, Jonathan L. ; Pericak-Vance, Margaret A. / Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K). In: Neuroscience Letters. 1999 ; Vol. 269, No. 2. pp. 115-119.
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