Analysis of association at single nucleotide polymorphisms in the APOE region

Eden R. Martin, John R. Gilbert, Eric H. Lai, John Riley, Allison R. Rogala, Brandon D. Slotterbeck, Catherine A. Sipe, Janet M. Grubber, Liling L. Warren, P. Michael Conneally, Ann M. Saunders, Donald E. Schmechel, Ian Purvis, Margaret A. Pericak-Vance, Allen D. Roses, Jeffery M. Vance

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

The discussion of the prospects of using a dense map of single nucleotide polymorphisms (SNPs) to identify disease genes with association analysis has been extensive. However, there is little empiric evidence to support this strategy. To begin to examine the practical issues surrounding this methodology, we identified 10 SNPs in the region immediately surrounding the apolipoprotein E locus (APOE), an established susceptibility gene for Alzheimer disease. Our goal was to examine patterns of allelic association to begin to investigate the question of whether APOE could have been identified using SNPs. Our strongest evidence of association was at the 2 SNPs immediately flanking APOE. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)7-12
Number of pages6
JournalGenomics
Volume63
Issue number1
DOIs
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Genetics

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