Analysis of association at single nucleotide polymorphisms in the APOE region

Eden R Martin, John Gilbert, Eric H. Lai, John Riley, Allison R. Rogala, Brandon D. Slotterbeck, Catherine A. Sipe, Janet M. Grubber, Liling L. Warren, P. Michael Conneally, Ann M. Saunders, Donald E. Schmechel, Ian Purvis, Margaret A Pericak-Vance, Allen D. Roses, Jeffery M Vance

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The discussion of the prospects of using a dense map of single nucleotide polymorphisms (SNPs) to identify disease genes with association analysis has been extensive. However, there is little empiric evidence to support this strategy. To begin to examine the practical issues surrounding this methodology, we identified 10 SNPs in the region immediately surrounding the apolipoprotein E locus (APOE), an established susceptibility gene for Alzheimer disease. Our goal was to examine patterns of allelic association to begin to investigate the question of whether APOE could have been identified using SNPs. Our strongest evidence of association was at the 2 SNPs immediately flanking APOE. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)7-12
Number of pages6
JournalGenomics
Volume63
Issue number1
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

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Apolipoproteins E
Single Nucleotide Polymorphism
Genes
Alzheimer Disease

ASJC Scopus subject areas

  • Genetics

Cite this

Analysis of association at single nucleotide polymorphisms in the APOE region. / Martin, Eden R; Gilbert, John; Lai, Eric H.; Riley, John; Rogala, Allison R.; Slotterbeck, Brandon D.; Sipe, Catherine A.; Grubber, Janet M.; Warren, Liling L.; Conneally, P. Michael; Saunders, Ann M.; Schmechel, Donald E.; Purvis, Ian; Pericak-Vance, Margaret A; Roses, Allen D.; Vance, Jeffery M.

In: Genomics, Vol. 63, No. 1, 01.01.2000, p. 7-12.

Research output: Contribution to journalArticle

Martin, ER, Gilbert, J, Lai, EH, Riley, J, Rogala, AR, Slotterbeck, BD, Sipe, CA, Grubber, JM, Warren, LL, Conneally, PM, Saunders, AM, Schmechel, DE, Purvis, I, Pericak-Vance, MA, Roses, AD & Vance, JM 2000, 'Analysis of association at single nucleotide polymorphisms in the APOE region', Genomics, vol. 63, no. 1, pp. 7-12. https://doi.org/10.1006/geno.1999.6057
Martin ER, Gilbert J, Lai EH, Riley J, Rogala AR, Slotterbeck BD et al. Analysis of association at single nucleotide polymorphisms in the APOE region. Genomics. 2000 Jan 1;63(1):7-12. https://doi.org/10.1006/geno.1999.6057
Martin, Eden R ; Gilbert, John ; Lai, Eric H. ; Riley, John ; Rogala, Allison R. ; Slotterbeck, Brandon D. ; Sipe, Catherine A. ; Grubber, Janet M. ; Warren, Liling L. ; Conneally, P. Michael ; Saunders, Ann M. ; Schmechel, Donald E. ; Purvis, Ian ; Pericak-Vance, Margaret A ; Roses, Allen D. ; Vance, Jeffery M. / Analysis of association at single nucleotide polymorphisms in the APOE region. In: Genomics. 2000 ; Vol. 63, No. 1. pp. 7-12.
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