Abstract
Aims: To examine whether polymorphic variants of the HTR2C gene are associated with diagnosis of alcohol dependence. Methods: We compared allele frequencies of five HTR2C promoter polymorphisms in a Nordic population of alcohol dependent individuals (Males: n = 309; Females: n = 127) and ethnically matched controls (Males: n = 83; Females: n = 190) in whom alcohol dependence was established, or any diagnosis of substance disorder was excluded, respectively. Patients were further subtyped into Type I (late onset) and Type II (early onset) alcoholics. Results: None of the individual polymorphisms indicated significant association with alcohol dependence. A common promoter haplotype (GAGG) exhibited different distribution frequencies between males and females (Type I), however on Bonferroni's multiple-testing correction, this observation proved to be insignificant. Conclusions: Although we report a lack of association between alcohol dependence and five common promoter polymorphisms, and the constituted haplotypes, the analysis tends to indicate gender and sub-type differences. We suggest that a follow up study with larger sample numbers should be performed to improve the power to detect the genetic influences of HTR2C in alcohol dependence.
| Original language | English |
|---|---|
| Pages (from-to) | 380-385 |
| Number of pages | 6 |
| Journal | Alcohol and Alcoholism |
| Volume | 39 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 1 2004 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
- Toxicology
Cite this
Analysis of 5-hydroxytryptamine 2C receptor gene promoter variants as alcohol-dependence risk factors. / Mottagui-Tabar, Salim; McCarthy, Shane; Reinemund, Jana; Andersson, Björn; Wahlestedt, Claes R; Heilig, Markus.
In: Alcohol and Alcoholism, Vol. 39, No. 5, 01.09.2004, p. 380-385.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of 5-hydroxytryptamine 2C receptor gene promoter variants as alcohol-dependence risk factors
AU - Mottagui-Tabar, Salim
AU - McCarthy, Shane
AU - Reinemund, Jana
AU - Andersson, Björn
AU - Wahlestedt, Claes R
AU - Heilig, Markus
PY - 2004/9/1
Y1 - 2004/9/1
N2 - Aims: To examine whether polymorphic variants of the HTR2C gene are associated with diagnosis of alcohol dependence. Methods: We compared allele frequencies of five HTR2C promoter polymorphisms in a Nordic population of alcohol dependent individuals (Males: n = 309; Females: n = 127) and ethnically matched controls (Males: n = 83; Females: n = 190) in whom alcohol dependence was established, or any diagnosis of substance disorder was excluded, respectively. Patients were further subtyped into Type I (late onset) and Type II (early onset) alcoholics. Results: None of the individual polymorphisms indicated significant association with alcohol dependence. A common promoter haplotype (GAGG) exhibited different distribution frequencies between males and females (Type I), however on Bonferroni's multiple-testing correction, this observation proved to be insignificant. Conclusions: Although we report a lack of association between alcohol dependence and five common promoter polymorphisms, and the constituted haplotypes, the analysis tends to indicate gender and sub-type differences. We suggest that a follow up study with larger sample numbers should be performed to improve the power to detect the genetic influences of HTR2C in alcohol dependence.
AB - Aims: To examine whether polymorphic variants of the HTR2C gene are associated with diagnosis of alcohol dependence. Methods: We compared allele frequencies of five HTR2C promoter polymorphisms in a Nordic population of alcohol dependent individuals (Males: n = 309; Females: n = 127) and ethnically matched controls (Males: n = 83; Females: n = 190) in whom alcohol dependence was established, or any diagnosis of substance disorder was excluded, respectively. Patients were further subtyped into Type I (late onset) and Type II (early onset) alcoholics. Results: None of the individual polymorphisms indicated significant association with alcohol dependence. A common promoter haplotype (GAGG) exhibited different distribution frequencies between males and females (Type I), however on Bonferroni's multiple-testing correction, this observation proved to be insignificant. Conclusions: Although we report a lack of association between alcohol dependence and five common promoter polymorphisms, and the constituted haplotypes, the analysis tends to indicate gender and sub-type differences. We suggest that a follow up study with larger sample numbers should be performed to improve the power to detect the genetic influences of HTR2C in alcohol dependence.
UR - http://www.scopus.com/inward/record.url?scp=4544278538&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4544278538&partnerID=8YFLogxK
U2 - 10.1093/alcalc/agh086
DO - 10.1093/alcalc/agh086
M3 - Article
C2 - 15304380
AN - SCOPUS:4544278538
VL - 39
SP - 380
EP - 385
JO - Alcohol and Alcoholism
JF - Alcohol and Alcoholism
SN - 0735-0414
IS - 5
ER -