Analysis and simulation of rare cell detection and size based profiling using counted micro-hall detectors

Rajapaksha W.R.L. Gajasinghe, Andrew Gabriel, Onur Tigli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

We present a comprehensive analysis and finite element method (FEM) modeling and simulations on using magnetic nanoparticles (MNPs) and Hall effect principles to detect, and estimate sizes of rare cells. In this model, rare cells labeled with MNPs are detected in-flow using coupled micro Hall voltage detectors (μHD). The voltage signals of μHDs are then analyzed to obtain size estimates. No physical contact, stressing, electrical excitation or immobilizing of cells is used. Voltage variations based on sensor dimensions, vertical separation distances and cell sizes were analyzed in simulations using finite element method. A signal processing algorithm was developed to determine cell size from detected voltages of bottom/top μHDs. This novel 2D dual μHD concept offers better accuracy when compared to conventional single μHD approach in cell count and also provide size profiling with 12.2% average error for cell diameters from 10 μm to 26 μm.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014
PublisherNano Science and Technology Institute
Pages65-68
Number of pages4
ISBN (Print)9781482258271
StatePublished - Jan 1 2014
EventNanotechnology 2014: MEMS, Fluidics, Bio Systems, Medical, Computational and Photonics - 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014 - Washington, DC, United States
Duration: Jun 15 2014Jun 18 2014

Publication series

NameTechnical Proceedings of the 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014
Volume2

Other

OtherNanotechnology 2014: MEMS, Fluidics, Bio Systems, Medical, Computational and Photonics - 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014
CountryUnited States
CityWashington, DC
Period6/15/146/18/14

Keywords

  • Cell size profiling
  • Hall effect sensors
  • Magnetic nanoparticles
  • Rare cell detection
  • Single cell analysis

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials

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  • Cite this

    Gajasinghe, R. W. R. L., Gabriel, A., & Tigli, O. (2014). Analysis and simulation of rare cell detection and size based profiling using counted micro-hall detectors. In Technical Proceedings of the 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014 (pp. 65-68). (Technical Proceedings of the 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014; Vol. 2). Nano Science and Technology Institute.