An update on the hepatitis E virus.

Seth N. Sclair, Eugene R Schiff

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

There have been recent key advances in the understanding of hepatitis E virus infection. Since the early 1980s, when the virus was first discovered, hepatitis E has been described as a disease that is endemic only in the African and Asian subcontinents, a disease that is transmitted via the fecal-oral route, and a disease that causes an acute illness that typically resolves, with the exception of the third trimester of pregnancy, when infection can be deadly. We now know that genotype 3 is likely a porcine zoonotic disease that is quite prevalent in certain industrialized nations. Hepatitis E carries high morbidity and mortality in patients with underlying liver disease and can become a chronic infection that causes fibrosis in immunocompromised hosts. Lastly, two vaccines have been developed and studied in clinical trials, with excellent results.

Original languageEnglish
JournalCurrent Gastroenterology Reports
Volume15
Issue number2
DOIs
StatePublished - Feb 1 2013

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Hepatitis E
Hepatitis E virus
Swine Diseases
Endemic Diseases
Zoonoses
Third Pregnancy Trimester
Immunocompromised Host
Acute Disease
Virus Diseases
Infection
Developed Countries
Liver Diseases
Fibrosis
Vaccines
Genotype
Clinical Trials
Viruses
Morbidity
Mortality

ASJC Scopus subject areas

  • Gastroenterology

Cite this

An update on the hepatitis E virus. / Sclair, Seth N.; Schiff, Eugene R.

In: Current Gastroenterology Reports, Vol. 15, No. 2, 01.02.2013.

Research output: Contribution to journalArticle

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