An update on the hepatitis e virus

Seth N. Sclair, Eugene R. Schiff

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

There have been recent key advances in the understanding of hepatitis E virus infection. Since the early 1980s, when the virus was first discovered, hepatitis E has been described as a disease that is endemic only in the African and Asian subcontinents, a disease that is transmitted via the fecal-oral route, and a disease that causes an acute illness that typically resolves, with the exception of the third trimester of pregnancy, when infection can be deadly. We now know that genotype 3 is likely a porcine zoonotic disease that is quite prevalent in certain industrialized nations. Hepatitis E carries high morbidity and mortality in patients with underlying liver disease and can become a chronic infection that causes fibrosis in immunocompromised hosts. Lastly, two vaccines have been developed and studied in clinical trials, with excellent results.

Original languageEnglish (US)
Article number304
JournalCurrent gastroenterology reports
Volume15
Issue number2
DOIs
StatePublished - Feb 2013

Keywords

  • Chronic liver disease
  • Cirrhosis
  • DILI
  • Hepatitis
  • Hepatitis E
  • Pregnancy
  • Ribavirin
  • Transplantation
  • Vaccine
  • Zoonosis

ASJC Scopus subject areas

  • Gastroenterology

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