Purpose of review: To review new clinically relevant data regarding the cause and treatment of scleritis that has been identified over the past 36 months. Recent findings: A recently described T-helper cell population, known as Th-17, has been implicated in scleritis. Large-scale, retrospective reviews of standard corticosteroid-sparing systemic therapies, published in the last few years, have demonstrated only moderate efficacy for any particular immunomodulatory agent, whereas new data have confirmed excellent efficacy and tolerability to subconjunctival corticosteroids. Summary: Improved understanding of the immunopathophysiology of scleritis offers hope for future molecule-specific drug design. Data continue to support the use of local steroids as a reasonable therapeutic option for nonnecrotizing, noninfectious anterior scleritis.
- noninfectious anterior scleritis
- ocular disease
ASJC Scopus subject areas
An update on the cause and treatment of scleritis. / Rachitskaya, Aleksandra; Mandelcorn, Efrem D.; Albini, Thomas A.In: Current Opinion in Ophthalmology, Vol. 21, No. 6, 01.11.2010, p. 463-467.
Research output: Contribution to journal › Article
TY - JOUR
T1 - An update on the cause and treatment of scleritis
AU - Rachitskaya, Aleksandra
AU - Mandelcorn, Efrem D.
AU - Albini, Thomas A
PY - 2010/11/1
Y1 - 2010/11/1
N2 - Lippincott Williams & Wilkins.
AB - Lippincott Williams & Wilkins.
KW - noninfectious anterior scleritis
KW - ocular disease
KW - scleritis
UR - http://www.scopus.com/inward/record.url?scp=78049288568&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78049288568&partnerID=8YFLogxK
U2 - 10.1097/ICU.0b013e32833f1060
DO - 10.1097/ICU.0b013e32833f1060
M3 - Article
C2 - 20842032
AN - SCOPUS:78049288568
VL - 21
SP - 463
EP - 467
JO - Current Opinion in Ophthalmology
JF - Current Opinion in Ophthalmology
SN - 1040-8738
IS - 6