An unusual insertion in intron 2 of apparently functional MHC class I alleles in rhesus macaques

J. A. Urvater, S. R. Steffen, W. Rehrauer, David Watkins

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Here we describe a nucleotide insertion in intron 2 of two rhesus major histocompatibility complex (MHC) class I alleles, Mamu-A*05 and Mamu-A*07. This resulted in an intron 2 that was nearly twice the length of any other intron 2 of primate MHC class I genes sequenced to date. This insertion was most similar (93% identity) to the beginning of intron 3 of HLA-A alleles. It was also similar to intron 3 of several human MHC class I pseudogenes and MHC class I pseduogenes from cotton top tamarin and cat. The finding of this insertion in two rhesus MHC class I genes is surprising given the uniformity in length and sequence of introns of functional HLA-A, -B and -C genes.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalTissue Antigens
Volume55
Issue number2
DOIs
StatePublished - Mar 1 2000
Externally publishedYes

Fingerprint

Major Histocompatibility Complex
Macaca mulatta
Introns
Alleles
MHC Class I Genes
HLA-A Antigens
Pseudogenes
HLA-B Antigens
Primates
Cats
Nucleotides
Genes

Keywords

  • Evolution
  • Intron
  • MHC class I
  • Rhesus macaque

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

An unusual insertion in intron 2 of apparently functional MHC class I alleles in rhesus macaques. / Urvater, J. A.; Steffen, S. R.; Rehrauer, W.; Watkins, David.

In: Tissue Antigens, Vol. 55, No. 2, 01.03.2000, p. 153-156.

Research output: Contribution to journalArticle

Urvater, J. A. ; Steffen, S. R. ; Rehrauer, W. ; Watkins, David. / An unusual insertion in intron 2 of apparently functional MHC class I alleles in rhesus macaques. In: Tissue Antigens. 2000 ; Vol. 55, No. 2. pp. 153-156.
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