Abstract
Here we describe a nucleotide insertion in intron 2 of two rhesus major histocompatibility complex (MHC) class I alleles, Mamu-A*05 and Mamu-A*07. This resulted in an intron 2 that was nearly twice the length of any other intron 2 of primate MHC class I genes sequenced to date. This insertion was most similar (93% identity) to the beginning of intron 3 of HLA-A alleles. It was also similar to intron 3 of several human MHC class I pseudogenes and MHC class I pseduogenes from cotton top tamarin and cat. The finding of this insertion in two rhesus MHC class I genes is surprising given the uniformity in length and sequence of introns of functional HLA-A, -B and -C genes.
| Original language | English |
|---|---|
| Pages (from-to) | 153-156 |
| Number of pages | 4 |
| Journal | Tissue Antigens |
| Volume | 55 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1 2000 |
| Externally published | Yes |
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Keywords
- Evolution
- Intron
- MHC class I
- Rhesus macaque
ASJC Scopus subject areas
- Immunology
- Cell Biology
Cite this
An unusual insertion in intron 2 of apparently functional MHC class I alleles in rhesus macaques. / Urvater, J. A.; Steffen, S. R.; Rehrauer, W.; Watkins, David.
In: Tissue Antigens, Vol. 55, No. 2, 01.03.2000, p. 153-156.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An unusual insertion in intron 2 of apparently functional MHC class I alleles in rhesus macaques
AU - Urvater, J. A.
AU - Steffen, S. R.
AU - Rehrauer, W.
AU - Watkins, David
PY - 2000/3/1
Y1 - 2000/3/1
N2 - Here we describe a nucleotide insertion in intron 2 of two rhesus major histocompatibility complex (MHC) class I alleles, Mamu-A*05 and Mamu-A*07. This resulted in an intron 2 that was nearly twice the length of any other intron 2 of primate MHC class I genes sequenced to date. This insertion was most similar (93% identity) to the beginning of intron 3 of HLA-A alleles. It was also similar to intron 3 of several human MHC class I pseudogenes and MHC class I pseduogenes from cotton top tamarin and cat. The finding of this insertion in two rhesus MHC class I genes is surprising given the uniformity in length and sequence of introns of functional HLA-A, -B and -C genes.
AB - Here we describe a nucleotide insertion in intron 2 of two rhesus major histocompatibility complex (MHC) class I alleles, Mamu-A*05 and Mamu-A*07. This resulted in an intron 2 that was nearly twice the length of any other intron 2 of primate MHC class I genes sequenced to date. This insertion was most similar (93% identity) to the beginning of intron 3 of HLA-A alleles. It was also similar to intron 3 of several human MHC class I pseudogenes and MHC class I pseduogenes from cotton top tamarin and cat. The finding of this insertion in two rhesus MHC class I genes is surprising given the uniformity in length and sequence of introns of functional HLA-A, -B and -C genes.
KW - Evolution
KW - Intron
KW - MHC class I
KW - Rhesus macaque
UR - http://www.scopus.com/inward/record.url?scp=0033965392&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033965392&partnerID=8YFLogxK
U2 - 10.1034/j.1399-0039.2000.550207.x
DO - 10.1034/j.1399-0039.2000.550207.x
M3 - Article
C2 - 10746787
AN - SCOPUS:0033965392
VL - 55
SP - 153
EP - 156
JO - HLA
JF - HLA
SN - 2059-2302
IS - 2
ER -