An unusual insertion in intron 2 of apparently functional MHC class I alleles in rhesus macaques

J. A. Urvater, S. R. Steffen, W. Rehrauer, D. I. Watkins

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Here we describe a nucleotide insertion in intron 2 of two rhesus major histocompatibility complex (MHC) class I alleles, Mamu-A*05 and Mamu-A*07. This resulted in an intron 2 that was nearly twice the length of any other intron 2 of primate MHC class I genes sequenced to date. This insertion was most similar (93% identity) to the beginning of intron 3 of HLA-A alleles. It was also similar to intron 3 of several human MHC class I pseudogenes and MHC class I pseduogenes from cotton top tamarin and cat. The finding of this insertion in two rhesus MHC class I genes is surprising given the uniformity in length and sequence of introns of functional HLA-A, -B and -C genes.

Original languageEnglish (US)
Pages (from-to)153-156
Number of pages4
JournalTissue Antigens
Volume55
Issue number2
DOIs
StatePublished - Mar 1 2000
Externally publishedYes

Keywords

  • Evolution
  • Intron
  • MHC class I
  • Rhesus macaque

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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