An unexpected twist in alopecia areata pathogenesis: Are NK cells protective and CD49b+ T cells pathogenic?

Gil Kaufman, Roberto d'Ovidio, Anis Kaldawy, Bedia Assy, Yehuda Ullmann, Amos Etzioni, Ralf Paus, Amos Gilhar

Research output: Contribution to journalLetter

23 Citations (Scopus)

Abstract

Natural killer (NK) cells have become a recent focus of interest in alopecia areata (AA) research. To further investigate their role in an established mouse model of AA, lesional skin from older C3H/HeJ mice with AA was grafted to young C3H/HeJ female mice, and NK cells were depleted by continuous administration of rabbit anti-asialo GM1. As expected, this significantly reduced the number of pure NK cells in murine skin, as assessed by NKp46 quantitative immunohistochemistry. Quite unexpectedly, however, the onset of hair loss in C3H/HeJ mice was accelerated, rather than retarded. NK cell depletion was accompanied by a significant increase in the number of perifollicular CD49b+T cells in the alopecic skin of anti-asialo GM1-treated mice. These findings underscore the need to carefully distinguish in future AA research between pure NK cells and defined subsets of CD49b+ lymphocytes, as they may exert diametrically opposed functions in hair follicle immunology and immunopathology.

Original languageEnglish (US)
JournalExperimental Dermatology
Volume19
Issue number8
DOIs
StatePublished - Aug 1 2010
Externally publishedYes

Fingerprint

Alopecia Areata
T-cells
Natural Killer Cells
Skin
T-Lymphocytes
Immunology
Inbred C3H Mouse
Lymphocytes
Hair Follicle
Alopecia
Lymphocyte Subsets
Allergy and Immunology
Research
Immunohistochemistry
Rabbits
asialo GM1 ganglioside

Keywords

  • Alopecia Areata
  • Autoimmunity
  • CD49b+ cells
  • NK cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

An unexpected twist in alopecia areata pathogenesis : Are NK cells protective and CD49b+ T cells pathogenic? / Kaufman, Gil; d'Ovidio, Roberto; Kaldawy, Anis; Assy, Bedia; Ullmann, Yehuda; Etzioni, Amos; Paus, Ralf; Gilhar, Amos.

In: Experimental Dermatology, Vol. 19, No. 8, 01.08.2010.

Research output: Contribution to journalLetter

Kaufman, Gil ; d'Ovidio, Roberto ; Kaldawy, Anis ; Assy, Bedia ; Ullmann, Yehuda ; Etzioni, Amos ; Paus, Ralf ; Gilhar, Amos. / An unexpected twist in alopecia areata pathogenesis : Are NK cells protective and CD49b+ T cells pathogenic?. In: Experimental Dermatology. 2010 ; Vol. 19, No. 8.
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