An rna toolbox for cancer immunotherapy

Fernando Pastor, Pedro Berraondo, Iñaki Etxeberria, Josh Frederick, Ugur Sahin, Eli Gilboa, Ignacio Melero

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

| Cancer immunotherapy has revolutionized oncology practice. However, current protein and cell therapy tools used in cancer immunotherapy are far from perfect, and there is room for improvement regarding their efficacy and safety. RNA-based structures have diverse functions, ranging from gene expression and gene regulation to pro-inflammatory effects and the ability to specifically bind different molecules. These functions make them versatile tools that may advance cancer vaccines and immunomodulation, surpassing existing approaches. These technologies should not be considered as competitors of current immunotherapies but as partners in synergistic combinations and as a clear opportunity to reach more efficient and personalized results. RNA and RNA derivatives can be exploited therapeutically as a platform to encode protein sequences, provide innate pro-inflammatory signals to the immune system (such as those denoting viral infection), control the expression of other RNAs (including key immunosuppressive factors) post-transcriptionally and conform structural scaffoldings binding proteins that control immune cells by modifying their function. Nascent RNA immunotherapeutics include RNA vaccines encoding cancer neoantigens, mRNAs encoding immunomodulatory factors, viral RNA analogues, interference RNAs and protein-binding RNA aptamers. These approaches are already in early clinical development with promising safety and efficacy results.

Original languageEnglish (US)
Pages (from-to)751-767
Number of pages17
JournalNature Reviews Drug Discovery
Volume17
Issue number10
DOIs
StatePublished - Oct 1 2018

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ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Pastor, F., Berraondo, P., Etxeberria, I., Frederick, J., Sahin, U., Gilboa, E., & Melero, I. (2018). An rna toolbox for cancer immunotherapy. Nature Reviews Drug Discovery, 17(10), 751-767. https://doi.org/10.1038/nrd.2018.132