An overview of HCV molecular biology, replication and immune responses

Usman A. Ashfaq, Tariq Javed, Sidra Rehman, Zafar Nawaz, Sheikh Riazuddin

Research output: Contribution to journalArticlepeer-review

119 Scopus citations


Hepatitis C virus (HCV) causes acute and chronic hepatitis which can eventually lead to permanent liver damage, hepatocellular carcinoma and death. Currently, there is no vaccine available for prevention of HCV infection due to high degree of strain variation. The current treatment of care, Pegylated interferon in combination with ribavirin is costly, has significant side effects and fails to cure about half of all infections. In this review, we summarize molecular virology, replication and immune responses against HCV and discussed how HCV escape from adaptive and humoral immune responses. This advance knowledge will be helpful for development of vaccine against HCV and discovery of new medicines both from synthetic chemistry and natural sources.

Original languageEnglish (US)
Article number161
JournalVirology Journal
StatePublished - 2011


  • HCV
  • HCV entry
  • immune responses
  • replication

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


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