An overview of HCV molecular biology, replication and immune responses

Usman A. Ashfaq, Tariq Javed, Sidra Rehman, Zafar Nawaz, Sheikh Riazuddin

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Hepatitis C virus (HCV) causes acute and chronic hepatitis which can eventually lead to permanent liver damage, hepatocellular carcinoma and death. Currently, there is no vaccine available for prevention of HCV infection due to high degree of strain variation. The current treatment of care, Pegylated interferon in combination with ribavirin is costly, has significant side effects and fails to cure about half of all infections. In this review, we summarize molecular virology, replication and immune responses against HCV and discussed how HCV escape from adaptive and humoral immune responses. This advance knowledge will be helpful for development of vaccine against HCV and discovery of new medicines both from synthetic chemistry and natural sources.

Original languageEnglish
Article number161
JournalVirology Journal
Volume8
DOIs
StatePublished - Apr 13 2011

Fingerprint

Hepacivirus
Molecular Biology
Vaccines
Virology
Ribavirin
Adaptive Immunity
Virus Diseases
Chronic Hepatitis
Humoral Immunity
Interferons
Hepatocellular Carcinoma
Liver
Infection

Keywords

  • HCV
  • HCV entry
  • immune responses
  • replication

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

An overview of HCV molecular biology, replication and immune responses. / Ashfaq, Usman A.; Javed, Tariq; Rehman, Sidra; Nawaz, Zafar; Riazuddin, Sheikh.

In: Virology Journal, Vol. 8, 161, 13.04.2011.

Research output: Contribution to journalArticle

Ashfaq, Usman A. ; Javed, Tariq ; Rehman, Sidra ; Nawaz, Zafar ; Riazuddin, Sheikh. / An overview of HCV molecular biology, replication and immune responses. In: Virology Journal. 2011 ; Vol. 8.
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