An oriented phase-II trial of d-Trp6-LH-RH in patients with prostatic carcinoma

G. Mathé, M. L. Vovan, J. Duchier, J. L. Misset, P. Morin, R. Keiling, L. Schwarzenberg, P. Kerbrat, E. Achille, J. C. Tronc, D. Machover, J. P. Fendler, E. Pappo, R. Metz, G. Prévot, A. M. Comaru-Schally, A. V. Schally

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Abstract

An oriented phase II trial of D-Trp6-LH-RH was conducted according to Gehan's statistical method on 25 patients suffering from prostatic carcinoma. LH and testosterone serum levels decreased rapidly. Pain disappeared during the third month in 14 out of the 21 patients and markedly decreased in 5. Prostatism completely regressed in 10 out of the 22 subjects presenting it and markedly decreased in 9. Prostate hypertrophy regressed as shown by ultrasonography, in 84% and by more than 50% in 37% of the patients. The overall regression rate of bone scintigraphy images was 43%; a regression of more than 50% was only registered in 12.5% of the patients; this may be explained by the long time which is necessary before bone image disappearance occurs. Prostatic acid phosphatase levels regressed in 75% and by more than 50% in 66.7% of the patients.

Original languageEnglish (US)
Pages (from-to)119-122
Number of pages4
JournalMedical Oncology and Tumor Pharmacotherapy
Volume1
Issue number2
DOIs
StatePublished - Jun 1 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Mathé, G., Vovan, M. L., Duchier, J., Misset, J. L., Morin, P., Keiling, R., Schwarzenberg, L., Kerbrat, P., Achille, E., Tronc, J. C., Machover, D., Fendler, J. P., Pappo, E., Metz, R., Prévot, G., Comaru-Schally, A. M., & Schally, A. V. (1984). An oriented phase-II trial of d-Trp6-LH-RH in patients with prostatic carcinoma. Medical Oncology and Tumor Pharmacotherapy, 1(2), 119-122. https://doi.org/10.1007/BF02934983