An open multiple instance learning framework and its application in drug activity prediction problems

Xin Huang, Shu Ching Chen, Mei Ling Shyu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

In this paper, a powerful open Multiple Instance Learning (MIL) framework is proposed. Such an open framework is powerful since different sub-methods can be plugged into the framework to generate different specific Multiple Instance Learning algorithms. In our proposed framework, the Multiple Instance Learning problem is first converted to an unconstrained optimization problem by the Minimum Square Error (MSE) criterion, and then the framework can be constructed with an open form of hypothesis and gradient search method. The proposed Multiple Instance Learning framework is applied to the drug activity problems in bioinformatics applications. Specifically, experiments are conducted on the Musk-1 dataset to predict the binding activity of drug molecules. In the experiments, an algorithm with the exponential hypothesis model and the Quasi-Newton method is embedded into our proposed framework. We compare our proposed framework with other existing algorithms and the experimental results show that our proposed framework yields a good accuracy of classification, which demonstrates the feasibility and effectiveness of our framework.

Original languageEnglish (US)
Title of host publicationProceedings - 3rd IEEE Symposium on BioInformatics and BioEngineering, BIBE 2003
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages53-59
Number of pages7
ISBN (Electronic)0769519075, 9780769519074
DOIs
StatePublished - 2003
Event3rd IEEE Symposium on BioInformatics and BioEngineering, BIBE 2003 - Bethesda, United States
Duration: Mar 10 2003Mar 12 2003

Publication series

NameProceedings - 3rd IEEE Symposium on BioInformatics and BioEngineering, BIBE 2003

Other

Other3rd IEEE Symposium on BioInformatics and BioEngineering, BIBE 2003
CountryUnited States
CityBethesda
Period3/10/033/12/03

Keywords

  • Bioinformatics
  • Machine learning
  • Multiple instance learning
  • Neural networks

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Signal Processing
  • Electrical and Electronic Engineering

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