An observer-blinded study of 1% permethrin creme rinse with and without adjunctive combing in patients with head lice

Terri L. Meinking, Coleen M. Clineschmidt, Cong Chen, Michael A. Kolber, Robert W. Tipping, Christine I. Furtek, Maria Elena Villar, Cynthia A. Guzzo

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Objectives: To determine if NIX (Warner Lambert Healthcare, Morris Plains, NJ) 1% Permethrin Creme Rinse Lice Treatment (1% PLT) without combing will effectively treat ≥95% of patients on day 2 or on day 15; to determine whether combing influences efficacy. Study design: A randomized, observer-blinded study enrolled 95 infested adults and children. All patients were treated with 1% PLT on day 1 and, if still infested, on day 8. One third of households were randomized to the combing group and two thirds to the no-combing group. Efficacy was assessed by: (1) visual inspection on days 1, 2, 8, 9, and 15 and, (2) shampooing/straining on days 2, 9, and 15. The target efficacy was 95%. Results: In the no-combing group, the lice-free rate was 83.1% on day 2 (95% CI, 71.0-91.6), 45.8% on day 8 (before second treatment) (95% CI, 32.7-59.2), 77.6% on day 9 (95% CI, 64.7-87.5), and 78.3% on day 15 (95% CI, 65.8-87.9). Adjunctive combing did not improve efficacy on any day. Conclusions: In this population, 1% PLT was significantly less than 95% effective and suggests resistance to 1% PLT. The failure of nit removal combing by nonprofessional caregivers to improve efficacy demonstrates the unreliability of combing as adjunctive treatment in this setting.

Original languageEnglish (US)
Pages (from-to)665-670
Number of pages6
JournalJournal of Pediatrics
Volume141
Issue number5
DOIs
StatePublished - Nov 1 2002

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Meinking, T. L., Clineschmidt, C. M., Chen, C., Kolber, M. A., Tipping, R. W., Furtek, C. I., Villar, M. E., & Guzzo, C. A. (2002). An observer-blinded study of 1% permethrin creme rinse with and without adjunctive combing in patients with head lice. Journal of Pediatrics, 141(5), 665-670. https://doi.org/10.1067/mpd.2002.129031