An LH-RH antagonist inhibits the behavioral effects of the agonist D-TRP-6-LH-RH in mice

Tibor Kádár, Gyula Telegdy, Andrew V. Schally

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The effects of a potent LH-RH receptor antagonist, [Ac-4-Cl-D-Phe1,2, D-Trp3,D-Arg6,D-Ala10]LH-RH (ORG 30276), on the behavioral actions of the LH-RH agonist, D-Trp-6-LH-RH, were studied in mice. The subcutaneous (SC) administration of 100 μg/kg D-Trp-6-LH-RH inhibited ambulation in an open-field, produced analgesia in the hot-plate and tail-flick tests. These effects of the agonist were totally antagonized by pre-treatment with ORG 30276 at a dose of 100 μg/kg SC. In the apomorphine-induced cage-climbing test, both the agonist and the antagonist alone or together suppressed the duration of stereotyped behaviod in dose-dependent manner, but, as there was no additive synergism after combined treatments, it seems that the two substances mutually diminish each other's effects. The results indicate that the behavioral effects of the LH-RH agonist can be antagonized by pretreatments with a potent LH-RH antagonist designed to block pituatary LH-RH receptors, with the exception of the suppression of apomorphine-induced cage-climbing, where special type of receptors and/or mechanisms might be involved.

Original languageEnglish (US)
Pages (from-to)665-668
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume41
Issue number4
DOIs
StatePublished - Apr 1992
Externally publishedYes

Keywords

  • Analgesia
  • Antistereotypic activity
  • LHRH agonist
  • LHRH antagonist
  • Luteinizing hormone-releasing hormone

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Fingerprint Dive into the research topics of 'An LH-RH antagonist inhibits the behavioral effects of the agonist D-TRP-6-LH-RH in mice'. Together they form a unique fingerprint.

  • Cite this