An L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension.

C. Lagenaur, V. Lemmon

Research output: Contribution to journalArticlepeer-review

386 Scopus citations

Abstract

The 8D9 antigen, a cell surface protein isolated from chicken brain that is related to the L1 class of cell adhesion molecules, is shown to contain an activity that promotes the attachment of neurons and the outgrowth of neurites from chicken tecta and mouse cerebellum. When purified 8D9 antigen is attached to a nitrocellulose-coated substrate, neurons rapidly attach and extend unfasciculated neurites. Little or no attachment of astroglia, oligodendroglia, and fibroblast-like cells to the 8D9 antigen is observed. We propose that a function of the 8D9 antigen is that of a neurite extension-promoting substrate in axon fascicles and in regeneration of peripheral nerves.

Original languageEnglish (US)
Pages (from-to)7753-7757
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume84
Issue number21
DOIs
StatePublished - Nov 1987
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'An L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension.'. Together they form a unique fingerprint.

Cite this