An L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension.

C. Lagenaur, Vance Lemmon

Research output: Contribution to journalArticle

379 Citations (Scopus)

Abstract

The 8D9 antigen, a cell surface protein isolated from chicken brain that is related to the L1 class of cell adhesion molecules, is shown to contain an activity that promotes the attachment of neurons and the outgrowth of neurites from chicken tecta and mouse cerebellum. When purified 8D9 antigen is attached to a nitrocellulose-coated substrate, neurons rapidly attach and extend unfasciculated neurites. Little or no attachment of astroglia, oligodendroglia, and fibroblast-like cells to the 8D9 antigen is observed. We propose that a function of the 8D9 antigen is that of a neurite extension-promoting substrate in axon fascicles and in regeneration of peripheral nerves.

Original languageEnglish
Pages (from-to)7753-7757
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume84
Issue number21
StatePublished - Nov 1 1987
Externally publishedYes

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Neurites
Antigens
Chickens
Neural Cell Adhesion Molecule L1
Neurons
Collodion
Oligodendroglia
Peripheral Nerves
Astrocytes
Cerebellum
Axons
Regeneration
Membrane Proteins
Fibroblasts
Brain

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

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N2 - The 8D9 antigen, a cell surface protein isolated from chicken brain that is related to the L1 class of cell adhesion molecules, is shown to contain an activity that promotes the attachment of neurons and the outgrowth of neurites from chicken tecta and mouse cerebellum. When purified 8D9 antigen is attached to a nitrocellulose-coated substrate, neurons rapidly attach and extend unfasciculated neurites. Little or no attachment of astroglia, oligodendroglia, and fibroblast-like cells to the 8D9 antigen is observed. We propose that a function of the 8D9 antigen is that of a neurite extension-promoting substrate in axon fascicles and in regeneration of peripheral nerves.

AB - The 8D9 antigen, a cell surface protein isolated from chicken brain that is related to the L1 class of cell adhesion molecules, is shown to contain an activity that promotes the attachment of neurons and the outgrowth of neurites from chicken tecta and mouse cerebellum. When purified 8D9 antigen is attached to a nitrocellulose-coated substrate, neurons rapidly attach and extend unfasciculated neurites. Little or no attachment of astroglia, oligodendroglia, and fibroblast-like cells to the 8D9 antigen is observed. We propose that a function of the 8D9 antigen is that of a neurite extension-promoting substrate in axon fascicles and in regeneration of peripheral nerves.

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