An interstitial deletion of the long arm of chromosome 21 in a case of a first episode of psychosis

J. Takhar, Ashok K. Malla, V. Siu, Colin MacPherson, Yao-Shan Fan, L. Townsend

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: Case of an interstitial deletion of the long arm of chromosome 21 presenting with first episode of psychosis. Method: A case report. Results: A 16-year-high school student of Somalian origin presented with a first episode of psychosis, mild mental retardation and dysmorphic features. Chromosome analysis revealed an interstitial deletion in the long arm of chromosome 21, described as 46, XX del (21) (q21q22.1). Conclusion: First episode of psychosis occurred in combination with neurobiological vulnerability and a complex genetic inheritance. The occurrence of psychosis in our case may be attributable to genes located within the region 21q21q22.1. The possibility that other loci exist on chromosome 21, which predispose to schizophrenia has to be considered. Identification of susceptibility genes will greatly facilitate investigation of factors that contribute to the disease process and may lead to early intervention and prevention.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalActa Psychiatrica Scandinavica
Volume106
Issue number1
DOIs
StatePublished - Aug 10 2002
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 21
Psychotic Disorders
Intellectual Disability
Genes
Schizophrenia
Chromosomes
Students

Keywords

  • Chromosome 21
  • Chromosome deletion
  • Genetics
  • Psychotic disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

An interstitial deletion of the long arm of chromosome 21 in a case of a first episode of psychosis. / Takhar, J.; Malla, Ashok K.; Siu, V.; MacPherson, Colin; Fan, Yao-Shan; Townsend, L.

In: Acta Psychiatrica Scandinavica, Vol. 106, No. 1, 10.08.2002, p. 71-74.

Research output: Contribution to journalArticle

Takhar, J. ; Malla, Ashok K. ; Siu, V. ; MacPherson, Colin ; Fan, Yao-Shan ; Townsend, L. / An interstitial deletion of the long arm of chromosome 21 in a case of a first episode of psychosis. In: Acta Psychiatrica Scandinavica. 2002 ; Vol. 106, No. 1. pp. 71-74.
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