An interstitial deletion of the long arm of chromosome 21 in a case of a first episode of psychosis

J. Takhar, Ashok K. Malla, V. Siu, Colin MacPherson, Y. S. Fan, L. Townsend

Research output: Contribution to journalArticle

8 Scopus citations


Objective: Case of an interstitial deletion of the long arm of chromosome 21 presenting with first episode of psychosis. Method: A case report. Results: A 16-year-high school student of Somalian origin presented with a first episode of psychosis, mild mental retardation and dysmorphic features. Chromosome analysis revealed an interstitial deletion in the long arm of chromosome 21, described as 46, XX del (21) (q21q22.1). Conclusion: First episode of psychosis occurred in combination with neurobiological vulnerability and a complex genetic inheritance. The occurrence of psychosis in our case may be attributable to genes located within the region 21q21q22.1. The possibility that other loci exist on chromosome 21, which predispose to schizophrenia has to be considered. Identification of susceptibility genes will greatly facilitate investigation of factors that contribute to the disease process and may lead to early intervention and prevention.

Original languageEnglish (US)
Pages (from-to)71-74
Number of pages4
JournalActa Psychiatrica Scandinavica
Issue number1
StatePublished - Jan 1 2002
Externally publishedYes



  • Chromosome 21
  • Chromosome deletion
  • Genetics
  • Psychotic disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

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