An integrated x-ray/optical tomography system for pre-clinical radiation research

S. Eslami, Yidong Yang, J. Wong, M. S. Patterson, I. Iordachita

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

The current Small Animal Radiation Research Platform (SARRP) is poor for localizing small soft tissue targets for irradiation or tumor models growing in a soft tissue environment. Therefore, an imaging method complementary to x-ray CT is required to localize the soft tissue target's Center of Mass (CoM) to within 1 mm. In this paper, we report the development of an integrated x-ray/bioluminescence imaging/tomography (BLI/BLT) system to provide a pre-clinical, high resolution irradiation system. This system can be used to study radiation effects in small animals under the conebeam computed tomography (CBCT) imaging guidance by adding the bioluminescence imaging (BLI) system as a standalone system which can also be docked onto the SARRP. The proposed system integrates two robotic rotating stages and an x-ray source rated at maximum 130 kVp and having a small variable focal spot. A high performance and low noise CCD camera mounted in a light-tight housing along with an optical filter assembly is used for multiwavelength BL tomography. A three-mirror arrangement is implemented to eliminate the need of rotating the CCD camera for acquiring multiple views. The mirror system is attached to a motorized stage to capture images in angles between 0-90° (for the standalone system). Camera and CBCT calibration are accomplished.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8668
DOIs
StatePublished - 2013
Externally publishedYes
EventMedical Imaging 2013: Physics of Medical Imaging - Lake Buena Vista, FL, United States
Duration: Feb 11 2013Feb 14 2013

Other

OtherMedical Imaging 2013: Physics of Medical Imaging
CountryUnited States
CityLake Buena Vista, FL
Period2/11/132/14/13

Fingerprint

Optical Tomography
Optical Devices
Optical tomography
Bioluminescence
bioluminescence
Tomography
tomography
X-Rays
Radiation
animals
X rays
Animals
radiation
Tissue
CCD cameras
Imaging techniques
Research
Imaging systems
Mirrors
x rays

Keywords

  • Bioluminescent tomography
  • CBCT
  • Small animal radiation research platform
  • X-ray

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Eslami, S., Yang, Y., Wong, J., Patterson, M. S., & Iordachita, I. (2013). An integrated x-ray/optical tomography system for pre-clinical radiation research. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8668). [866830] https://doi.org/10.1117/12.2008060

An integrated x-ray/optical tomography system for pre-clinical radiation research. / Eslami, S.; Yang, Yidong; Wong, J.; Patterson, M. S.; Iordachita, I.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8668 2013. 866830.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Eslami, S, Yang, Y, Wong, J, Patterson, MS & Iordachita, I 2013, An integrated x-ray/optical tomography system for pre-clinical radiation research. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8668, 866830, Medical Imaging 2013: Physics of Medical Imaging, Lake Buena Vista, FL, United States, 2/11/13. https://doi.org/10.1117/12.2008060
Eslami S, Yang Y, Wong J, Patterson MS, Iordachita I. An integrated x-ray/optical tomography system for pre-clinical radiation research. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8668. 2013. 866830 https://doi.org/10.1117/12.2008060
Eslami, S. ; Yang, Yidong ; Wong, J. ; Patterson, M. S. ; Iordachita, I. / An integrated x-ray/optical tomography system for pre-clinical radiation research. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8668 2013.
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