Abstract
The antifibrinolytic activity of cytosol from Dunning R3327H rat prostate tumors was studied. The prostate tumors from rats treated with D-Tryp6-LH-RH had 2.5 times lower plasminogen activator activity than tumors from untreated rats. This was due to the presence of an inhibitor of plasminogen activator as well as a reduction in residual activity of plasminogen activator(s). Only the cytosolic extracts from prostate tumors of rats treated with D-Trp6-LH-RH contained this inhibitor. The purified inhibitor (m.w. 21,000), formed a complex with urokinase and partially purified plasminogen activator(s) from prostate tumors of untreated as well as D-Trp6-LH-RH treated rats. The increase in antifibrinolytic activity after treatment with LH-RH analogs may be an important factor in reducing the invasiveness of the prostate tumor.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 124-135 |
| Number of pages | 12 |
| Journal | Hormone Research in Paediatrics |
| Volume | 21 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1985 |
| Externally published | Yes |
Keywords
- Antifibrinolytic activity
- Plasminogen activator inhibitor
- Rat prostate tumors
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Endocrinology, Diabetes and Metabolism
- Endocrinology
