An inhibitor of urokinase and tissue plasminogen activators in dunning R3327H prostate tumors of rats treated with D-Trp6-LH-RH

Marion T. Hierowski; Andrew V. Schally

doi:10.1159/000180036

An inhibitor of urokinase and tissue plasminogen activators in dunning R3327H prostate tumors of rats treated with D-Trp⁶-LH-RH

Marion T. Hierowski, Andrew V. Schally

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The antifibrinolytic activity of cytosol from Dunning R3327H rat prostate tumors was studied. The prostate tumors from rats treated with D-Tryp⁶-LH-RH had 2.5 times lower plasminogen activator activity than tumors from untreated rats. This was due to the presence of an inhibitor of plasminogen activator as well as a reduction in residual activity of plasminogen activator(s). Only the cytosolic extracts from prostate tumors of rats treated with D-Trp⁶-LH-RH contained this inhibitor. The purified inhibitor (m.w. 21,000), formed a complex with urokinase and partially purified plasminogen activator(s) from prostate tumors of untreated as well as D-Trp⁶-LH-RH treated rats. The increase in antifibrinolytic activity after treatment with LH-RH analogs may be an important factor in reducing the invasiveness of the prostate tumor.

Original language	English (US)
Pages (from-to)	124-135
Number of pages	12
Journal	Hormone Research in Paediatrics
Volume	21
Issue number	2
DOIs	https://doi.org/10.1159/000180036
State	Published - Jan 1 1985
Externally published	Yes

Keywords

Antifibrinolytic activity
Plasminogen activator inhibitor
Rat prostate tumors

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Endocrinology, Diabetes and Metabolism
Endocrinology

Access to Document

10.1159/000180036

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title = "An inhibitor of urokinase and tissue plasminogen activators in dunning R3327H prostate tumors of rats treated with D-Trp6-LH-RH",

abstract = "The antifibrinolytic activity of cytosol from Dunning R3327H rat prostate tumors was studied. The prostate tumors from rats treated with D-Tryp6-LH-RH had 2.5 times lower plasminogen activator activity than tumors from untreated rats. This was due to the presence of an inhibitor of plasminogen activator as well as a reduction in residual activity of plasminogen activator(s). Only the cytosolic extracts from prostate tumors of rats treated with D-Trp6-LH-RH contained this inhibitor. The purified inhibitor (m.w. 21,000), formed a complex with urokinase and partially purified plasminogen activator(s) from prostate tumors of untreated as well as D-Trp6-LH-RH treated rats. The increase in antifibrinolytic activity after treatment with LH-RH analogs may be an important factor in reducing the invasiveness of the prostate tumor.",

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N2 - The antifibrinolytic activity of cytosol from Dunning R3327H rat prostate tumors was studied. The prostate tumors from rats treated with D-Tryp6-LH-RH had 2.5 times lower plasminogen activator activity than tumors from untreated rats. This was due to the presence of an inhibitor of plasminogen activator as well as a reduction in residual activity of plasminogen activator(s). Only the cytosolic extracts from prostate tumors of rats treated with D-Trp6-LH-RH contained this inhibitor. The purified inhibitor (m.w. 21,000), formed a complex with urokinase and partially purified plasminogen activator(s) from prostate tumors of untreated as well as D-Trp6-LH-RH treated rats. The increase in antifibrinolytic activity after treatment with LH-RH analogs may be an important factor in reducing the invasiveness of the prostate tumor.

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