An inhibitor of urokinase and tissue plasminogen activators in dunning R3327H prostate tumors of rats treated with D-Trp6-LH-RH

Marion T. Hierowski, Andrew V. Schally

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The antifibrinolytic activity of cytosol from Dunning R3327H rat prostate tumors was studied. The prostate tumors from rats treated with D-Tryp6-LH-RH had 2.5 times lower plasminogen activator activity than tumors from untreated rats. This was due to the presence of an inhibitor of plasminogen activator as well as a reduction in residual activity of plasminogen activator(s). Only the cytosolic extracts from prostate tumors of rats treated with D-Trp6-LH-RH contained this inhibitor. The purified inhibitor (m.w. 21,000), formed a complex with urokinase and partially purified plasminogen activator(s) from prostate tumors of untreated as well as D-Trp6-LH-RH treated rats. The increase in antifibrinolytic activity after treatment with LH-RH analogs may be an important factor in reducing the invasiveness of the prostate tumor.

Original languageEnglish (US)
Pages (from-to)124-135
Number of pages12
JournalHormone Research in Paediatrics
Volume21
Issue number2
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Keywords

  • Antifibrinolytic activity
  • Plasminogen activator inhibitor
  • Rat prostate tumors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'An inhibitor of urokinase and tissue plasminogen activators in dunning R3327H prostate tumors of rats treated with D-Trp<sup>6</sup>-LH-RH'. Together they form a unique fingerprint.

Cite this