An inhibitor of urokinase and tissue plasminogen activators in dunning R3327H prostate tumors of rats treated with D-Trp6-LH-RH

Marion T. Hierowski; Andrew V. Schally

doi:10.1159/000180036

An inhibitor of urokinase and tissue plasminogen activators in dunning R3327H prostate tumors of rats treated with D-Trp⁶-LH-RH

Marion T. Hierowski, Andrew V. Schally

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

The antifibrinolytic activity of cytosol from Dunning R3327H rat prostate tumors was studied. The prostate tumors from rats treated with D-Tryp⁶-LH-RH had 2.5 times lower plasminogen activator activity than tumors from untreated rats. This was due to the presence of an inhibitor of plasminogen activator as well as a reduction in residual activity of plasminogen activator(s). Only the cytosolic extracts from prostate tumors of rats treated with D-Trp⁶-LH-RH contained this inhibitor. The purified inhibitor (m.w. 21,000), formed a complex with urokinase and partially purified plasminogen activator(s) from prostate tumors of untreated as well as D-Trp⁶-LH-RH treated rats. The increase in antifibrinolytic activity after treatment with LH-RH analogs may be an important factor in reducing the invasiveness of the prostate tumor.

Original language	English (US)
Pages (from-to)	124-135
Number of pages	12
Journal	Hormone Research in Paediatrics
Volume	21
Issue number	2
DOIs	https://doi.org/10.1159/000180036
State	Published - Jan 1 1985
Externally published	Yes

Keywords

Antifibrinolytic activity
Plasminogen activator inhibitor
Rat prostate tumors

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1159/000180036

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Hierowski, M. T., & Schally, A. V. (1985). An inhibitor of urokinase and tissue plasminogen activators in dunning R3327H prostate tumors of rats treated with D-Trp⁶-LH-RH. Hormone Research in Paediatrics, 21(2), 124-135. https://doi.org/10.1159/000180036

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