An inhibitor of urokinase and tissue plasminogen activators in Dunning R3327H prostate tumors of rats treated with D-Trp6-LH-RH

M. T. Hierowski, Andrew V Schally

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The antifibrinolytic activity of cytosol from Dunning R3327H rat prostate tumors was studied. The prostate tumors from rats treated with D-Tryp6-LH-RH had 2.5 times lower plasminogen activator activity than tumors from untreated rats. This was due to the presence of an inhibitor of plasminogen activator as well as a reduction in residual activity of plasminogen activator(s). Only the cytosolic extracts from prostate tumors of rats treated with D-Trp6-LH-RH contained this inhibitor. The purified inhibitor (m.w. 21,000), formed a complex with urokinase and partially purified plasminogen activator(s) from prostate tumors of untreated as well as D-Trp6-LH-RH treated rats. The increase in antifibrinolytic activity after treatment with LH-RH analogs may be an important factor in reducing the invasiveness of the prostate tumor.

Original languageEnglish
Pages (from-to)124-135
Number of pages12
JournalHormone Research
Volume21
Issue number2
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Tissue Plasminogen Activator
Gonadotropin-Releasing Hormone
Prostate
Plasminogen Activators
Neoplasms
Antifibrinolytic Agents
Plasminogen Inactivators
Urokinase-Type Plasminogen Activator
Cytosol
urokinase inhibitor

ASJC Scopus subject areas

  • Endocrinology

Cite this

An inhibitor of urokinase and tissue plasminogen activators in Dunning R3327H prostate tumors of rats treated with D-Trp6-LH-RH. / Hierowski, M. T.; Schally, Andrew V.

In: Hormone Research, Vol. 21, No. 2, 01.01.1985, p. 124-135.

Research output: Contribution to journalArticle

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