Abstract
Using thiamphenicol and scheduled bleeding, we were able to induce an adequate number of erythroid stem cells (CFU‐e) in mice in order to conduct an in vivo study of the changing expression of c‐myc and c‐fos oncogenes during erythropoiesis. Results indicated that c‐myc and c‐fos are active in erythropoiesis and have a similar pattern of expression. A large decrease in expression of both c‐myc and c‐fos occurs when erythroid cells begin the biochemical transition into mature phenotypes, i.e., when RNA synthesis is down‐regulated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 179-189 |
| Number of pages | 11 |
| Journal | The International Journal of Cell Cloning |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1989 |
| Externally published | Yes |
Keywords
- Erythroid differentiation
- Oncogenes
- Thiamphenicol
- c‐fos
- c‐myc
ASJC Scopus subject areas
- Cell Biology