An in Vivo Analysis of c‐myc and c‐fos Expression During Terminal Erythroid Differentiation in Mouse Spleen Progenitors

Research output: Contribution to journalArticle

Abstract

Using thiamphenicol and scheduled bleeding, we were able to induce an adequate number of erythroid stem cells (CFU‐e) in mice in order to conduct an in vivo study of the changing expression of c‐myc and c‐fos oncogenes during erythropoiesis. Results indicated that c‐myc and c‐fos are active in erythropoiesis and have a similar pattern of expression. A large decrease in expression of both c‐myc and c‐fos occurs when erythroid cells begin the biochemical transition into mature phenotypes, i.e., when RNA synthesis is down‐regulated.

Original languageEnglish (US)
Pages (from-to)179-189
Number of pages11
JournalThe International Journal of Cell Cloning
Volume7
Issue number3
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • Erythroid differentiation
  • Oncogenes
  • Thiamphenicol
  • c‐fos
  • c‐myc

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'An in Vivo Analysis of c‐myc and c‐fos Expression During Terminal Erythroid Differentiation in Mouse Spleen Progenitors'. Together they form a unique fingerprint.

  • Cite this