An in Vivo Analysis of c‐myc and c‐fos Expression During Terminal Erythroid Differentiation in Mouse Spleen Progenitors

Evangelos V. Badiavas; Hideko Kaji

doi:10.1002/stem.5530070305

An in Vivo Analysis of c‐myc and c‐fos Expression During Terminal Erythroid Differentiation in Mouse Spleen Progenitors

Research output: Contribution to journal › Article › peer-review

Abstract

Using thiamphenicol and scheduled bleeding, we were able to induce an adequate number of erythroid stem cells (CFU‐e) in mice in order to conduct an in vivo study of the changing expression of c‐myc and c‐fos oncogenes during erythropoiesis. Results indicated that c‐myc and c‐fos are active in erythropoiesis and have a similar pattern of expression. A large decrease in expression of both c‐myc and c‐fos occurs when erythroid cells begin the biochemical transition into mature phenotypes, i.e., when RNA synthesis is down‐regulated.

Original language	English (US)
Pages (from-to)	179-189
Number of pages	11
Journal	The International Journal of Cell Cloning
Volume	7
Issue number	3
DOIs	https://doi.org/10.1002/stem.5530070305
State	Published - 1989
Externally published	Yes

Keywords

Erythroid differentiation
Oncogenes
Thiamphenicol
c‐fos
c‐myc

ASJC Scopus subject areas

Cell Biology

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title = "An in Vivo Analysis of c‐myc and c‐fos Expression During Terminal Erythroid Differentiation in Mouse Spleen Progenitors",

abstract = "Using thiamphenicol and scheduled bleeding, we were able to induce an adequate number of erythroid stem cells (CFU‐e) in mice in order to conduct an in vivo study of the changing expression of c‐myc and c‐fos oncogenes during erythropoiesis. Results indicated that c‐myc and c‐fos are active in erythropoiesis and have a similar pattern of expression. A large decrease in expression of both c‐myc and c‐fos occurs when erythroid cells begin the biochemical transition into mature phenotypes, i.e., when RNA synthesis is down‐regulated.",

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AU - Badiavas, Evangelos V.

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Y1 - 1989

N2 - Using thiamphenicol and scheduled bleeding, we were able to induce an adequate number of erythroid stem cells (CFU‐e) in mice in order to conduct an in vivo study of the changing expression of c‐myc and c‐fos oncogenes during erythropoiesis. Results indicated that c‐myc and c‐fos are active in erythropoiesis and have a similar pattern of expression. A large decrease in expression of both c‐myc and c‐fos occurs when erythroid cells begin the biochemical transition into mature phenotypes, i.e., when RNA synthesis is down‐regulated.

AB - Using thiamphenicol and scheduled bleeding, we were able to induce an adequate number of erythroid stem cells (CFU‐e) in mice in order to conduct an in vivo study of the changing expression of c‐myc and c‐fos oncogenes during erythropoiesis. Results indicated that c‐myc and c‐fos are active in erythropoiesis and have a similar pattern of expression. A large decrease in expression of both c‐myc and c‐fos occurs when erythroid cells begin the biochemical transition into mature phenotypes, i.e., when RNA synthesis is down‐regulated.

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KW - c‐fos

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An in Vivo Analysis of c‐myc and c‐fos Expression During Terminal Erythroid Differentiation in Mouse Spleen Progenitors

Abstract

Keywords

ASJC Scopus subject areas

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