An in vitro evaluation of tetrahydrotriamcinolone

J. F. Bigger, H. A. Zink, P. F. Palmberg, B. Becker

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Abstract

In the search for steroids which do not elevate intraocular pressure tetrahydrotriamcinolone is one of the drugs for which this advantage is claimed. However its potency as an antiinflammatory agent is controversial. This elaborate laboratory investigation, using a peripheral blood lymphocyte inhibition assay, attempted to determine the potency of this drug relative to prednisolone 21 phosphate. The freshly heparinized venous blood used in the laboratory procedure was drawn from 15 patients from the glaucoma research department, of which 7 had primary open angle glaucoma with field loss, 6 did not respond to topical dexamethasone testing, and 2 were classified as high pressure responders without field loss. The laboratory technique and the data obtained are described in detail. The conclusion is that tetrahydrotriamcinolone acts no differently than weak glucocorticoids such as prednisolone, and the low incidence of ocular hypertension induced by it is due to its low antiinflammatory potency.

Original languageEnglish (US)
Pages (from-to)856-858
Number of pages3
JournalInvestigative ophthalmology
Volume12
Issue number11
StatePublished - Dec 1 1973
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Bigger, J. F., Zink, H. A., Palmberg, P. F., & Becker, B. (1973). An in vitro evaluation of tetrahydrotriamcinolone. Investigative ophthalmology, 12(11), 856-858.