An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory

Hyejin Kang, Linus D. Sun, Coleen M Atkins, Thomas R. Soderling, Matthew A. Wilson, Susumu Tonegawa

Research output: Contribution to journalArticle

217 Citations (Scopus)

Abstract

Calcium/calmodulin-dependent protein kinase IV (CaMKIV) has been implicated in the regulation of CRE-dependent transcription. To investigate the role of this kinase in neuronal plasticity and memory, we generated transgenic mice in which the expression of a dominant-negative form of CaMKIV (dnCaMKIV) is restricted to the postnatal forebrain. In these transgenic mice, activity-induced CREB phosphorylation and c-Fos expression were significantly attenuated. Hippocampal late LTP (L-LTP) was also impaired, whereas basic synaptic function and early LTP (E-LTP) were unaffected. These deficits correlated with impairments in long-term memory, specifically in its consolidation/retention phase but not in the acquisition phase. These results indicate that neural activity-dependent CaMKIV signaling in the neuronal nucleus plays an important role in the consolidation/retention of hippocampus-dependent long-term memory.

Original languageEnglish
Pages (from-to)771-783
Number of pages13
JournalCell
Volume106
Issue number6
DOIs
StatePublished - Sep 21 2001
Externally publishedYes

Fingerprint

Calcium-Calmodulin-Dependent Protein Kinase Type 4
Long-Term Memory
Consolidation
Data storage equipment
Transgenic Mice
Phosphorylation
Neuronal Plasticity
Transcription
Prosencephalon
Plasticity
Hippocampus
Phosphotransferases
Retention (Psychology)

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory. / Kang, Hyejin; Sun, Linus D.; Atkins, Coleen M; Soderling, Thomas R.; Wilson, Matthew A.; Tonegawa, Susumu.

In: Cell, Vol. 106, No. 6, 21.09.2001, p. 771-783.

Research output: Contribution to journalArticle

Kang, Hyejin ; Sun, Linus D. ; Atkins, Coleen M ; Soderling, Thomas R. ; Wilson, Matthew A. ; Tonegawa, Susumu. / An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory. In: Cell. 2001 ; Vol. 106, No. 6. pp. 771-783.
@article{f1b3cf9309424e4297796e3f51f1588b,
title = "An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory",
abstract = "Calcium/calmodulin-dependent protein kinase IV (CaMKIV) has been implicated in the regulation of CRE-dependent transcription. To investigate the role of this kinase in neuronal plasticity and memory, we generated transgenic mice in which the expression of a dominant-negative form of CaMKIV (dnCaMKIV) is restricted to the postnatal forebrain. In these transgenic mice, activity-induced CREB phosphorylation and c-Fos expression were significantly attenuated. Hippocampal late LTP (L-LTP) was also impaired, whereas basic synaptic function and early LTP (E-LTP) were unaffected. These deficits correlated with impairments in long-term memory, specifically in its consolidation/retention phase but not in the acquisition phase. These results indicate that neural activity-dependent CaMKIV signaling in the neuronal nucleus plays an important role in the consolidation/retention of hippocampus-dependent long-term memory.",
author = "Hyejin Kang and Sun, {Linus D.} and Atkins, {Coleen M} and Soderling, {Thomas R.} and Wilson, {Matthew A.} and Susumu Tonegawa",
year = "2001",
month = "9",
day = "21",
doi = "10.1016/S0092-8674(01)00497-4",
language = "English",
volume = "106",
pages = "771--783",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory

AU - Kang, Hyejin

AU - Sun, Linus D.

AU - Atkins, Coleen M

AU - Soderling, Thomas R.

AU - Wilson, Matthew A.

AU - Tonegawa, Susumu

PY - 2001/9/21

Y1 - 2001/9/21

N2 - Calcium/calmodulin-dependent protein kinase IV (CaMKIV) has been implicated in the regulation of CRE-dependent transcription. To investigate the role of this kinase in neuronal plasticity and memory, we generated transgenic mice in which the expression of a dominant-negative form of CaMKIV (dnCaMKIV) is restricted to the postnatal forebrain. In these transgenic mice, activity-induced CREB phosphorylation and c-Fos expression were significantly attenuated. Hippocampal late LTP (L-LTP) was also impaired, whereas basic synaptic function and early LTP (E-LTP) were unaffected. These deficits correlated with impairments in long-term memory, specifically in its consolidation/retention phase but not in the acquisition phase. These results indicate that neural activity-dependent CaMKIV signaling in the neuronal nucleus plays an important role in the consolidation/retention of hippocampus-dependent long-term memory.

AB - Calcium/calmodulin-dependent protein kinase IV (CaMKIV) has been implicated in the regulation of CRE-dependent transcription. To investigate the role of this kinase in neuronal plasticity and memory, we generated transgenic mice in which the expression of a dominant-negative form of CaMKIV (dnCaMKIV) is restricted to the postnatal forebrain. In these transgenic mice, activity-induced CREB phosphorylation and c-Fos expression were significantly attenuated. Hippocampal late LTP (L-LTP) was also impaired, whereas basic synaptic function and early LTP (E-LTP) were unaffected. These deficits correlated with impairments in long-term memory, specifically in its consolidation/retention phase but not in the acquisition phase. These results indicate that neural activity-dependent CaMKIV signaling in the neuronal nucleus plays an important role in the consolidation/retention of hippocampus-dependent long-term memory.

UR - http://www.scopus.com/inward/record.url?scp=0035929240&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035929240&partnerID=8YFLogxK

U2 - 10.1016/S0092-8674(01)00497-4

DO - 10.1016/S0092-8674(01)00497-4

M3 - Article

C2 - 11572782

AN - SCOPUS:0035929240

VL - 106

SP - 771

EP - 783

JO - Cell

JF - Cell

SN - 0092-8674

IS - 6

ER -