An experimental model for the study of hepatic encephalopathy

Michael D Norenberg, L. W. Lapham, F. A. Nichols, A. G. May

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

A subacute experimental model of hepatic encephalopathy was created in the rat by constructing a portacaval shunt with subsequent gavage feeding of a cationic ammonium exchange resin. The clinical course was characterized by fluctuating levels of consciousness, bizarre behavior, and motor symptoms leading to coma and death. Histopathologically, proliferation of Alzeimer type II astrocytes in the cerebral cortex was demonstrated. Serum ammonia levels were greatly elevated. This model should be useful in providing a better understanding of the pathogenesis of hepatic coma, and particularly the role of the astrocyte in this process.

Original languageEnglish
Pages (from-to)106-109
Number of pages4
JournalArchives of Neurology
Volume31
Issue number2
StatePublished - Dec 1 1974
Externally publishedYes

Fingerprint

Hepatic Encephalopathy
Astrocytes
Theoretical Models
Surgical Portacaval Shunt
Coma
Consciousness
Ammonium Compounds
Ammonia
Cerebral Cortex
Serum
Rat
Resin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Norenberg, M. D., Lapham, L. W., Nichols, F. A., & May, A. G. (1974). An experimental model for the study of hepatic encephalopathy. Archives of Neurology, 31(2), 106-109.

An experimental model for the study of hepatic encephalopathy. / Norenberg, Michael D; Lapham, L. W.; Nichols, F. A.; May, A. G.

In: Archives of Neurology, Vol. 31, No. 2, 01.12.1974, p. 106-109.

Research output: Contribution to journalArticle

Norenberg, MD, Lapham, LW, Nichols, FA & May, AG 1974, 'An experimental model for the study of hepatic encephalopathy', Archives of Neurology, vol. 31, no. 2, pp. 106-109.
Norenberg, Michael D ; Lapham, L. W. ; Nichols, F. A. ; May, A. G. / An experimental model for the study of hepatic encephalopathy. In: Archives of Neurology. 1974 ; Vol. 31, No. 2. pp. 106-109.
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