An exclusion map for facioscapulohumeral (Landouzy-Déjérine) disease

Mansoor S.Arfar Azi, Meena Upadhyaya, George Padberg, Margaret Pericak-Vance, Teepu Siddique, G. Lucotte, Peter Lunt

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

By using the genetic linkage data between the facioscapulohumeral muscular dystrophy (FSHD) gene and 57 markers on various autosomes, we have constructed an exclusion map for this disorder. The maximum likelihood location of the FSHD gene and the percentage of the excluded areas on each chromosome are presented here. This exclusion map shows that more than 80% of the genome has been excluded as a likely location of any locus responsible for FSHD in the majority of families. Chromosomes 3, 5, 10, 11, 15, and 19 remain largely unexcluded. Concentration on the highlighted areas of the genome should facilitate the identification of the site of the FSHD gene.

Original languageEnglish (US)
Pages (from-to)481-484
Number of pages4
JournalJournal of medical genetics
Volume26
Issue number8
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'An exclusion map for facioscapulohumeral (Landouzy-Déjérine) disease'. Together they form a unique fingerprint.

  • Cite this

    Azi, M. S. A., Upadhyaya, M., Padberg, G., Pericak-Vance, M., Siddique, T., Lucotte, G., & Lunt, P. (1989). An exclusion map for facioscapulohumeral (Landouzy-Déjérine) disease. Journal of medical genetics, 26(8), 481-484. https://doi.org/10.1136/jmg.26.8.481