An emerging cell-based strategy in orthopaedics: Endothelial progenitor cells

Kivanc Atesok, Tomoyuki Matsumoto, Jon Karlsson, Takayuki Asahara, Anthony Atala, M. Nedim Doral, Rene Verdonk, Ru Li, Emil Schemitsch

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Purpose: The purpose of this article was to analyze the results of studies in the literature, which evaluated the use of endothelial progenitor cells (EPCs) as a cell-based tissue engineering strategy. Methods: EPCs have been successfully used in regenerative medicine to augment neovascularization in patients after myocardial infarction and limb ischemia. EPCs' important role as vasculogenic progenitors presents them as a potential source for cell-based therapies to promote bone healing. Results: EPCs have been shown to have prominent effects in promoting bone regeneration in several animal models. Evidence indicates that EPCs promote bone regeneration by stimulating both angiogenesis and osteogenesis through a differentiation process toward endothelial cell lineage and formation of osteoblasts. Moreover, EPCs increase vascularization and osteogenesis by increased secretion of growth factors and cytokines through paracrine mechanisms. Conclusion: EPCs offer the potential to emerge as a new strategy among other cell-based therapies to promote bone regeneration. Further investigations and human trials are required to address current questions with regard to biology and mechanisms of action of EPCs in bone tissue engineering.

Original languageEnglish (US)
Pages (from-to)1366-1377
Number of pages12
JournalKnee Surgery, Sports Traumatology, Arthroscopy
Issue number7
StatePublished - Jul 2012
Externally publishedYes


  • Bone tissue engineering
  • Cell-based therapy
  • Endothelial progenitor cell (EPC)
  • Fracture healing

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery


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