An Effective Preoperative Three-Dimensional Radiotherapy Target Volume for Extremity Soft Tissue Sarcoma and the Effect of Margin Width on Local Control

Bo Kyong Kim, Yen Lin E. Chen, David G. Kirsch, Saveli I. Goldberg, Wendy Kobayashi, Jong Hyun Kung, John A. Wolfgang, Karen Doppke, Andrew E. Rosenberg, G. Petur Nielsen, Kevin A. Raskin, Dempsey S. Springfield, Joseph H. Schwab, Mark C. Gebhardt, Sam S. Yoon, Francis J. Hornicek, Thomas F. DeLaney

Research output: Contribution to journalArticle

34 Scopus citations


Purpose: There is little information on the appropriate three-dimensional (3D) preoperative radiotherapy (XRT) volume for extremity soft-tissue sarcomas (STS). We retrospectively analyzed the pattern of local failure (LF) to help elucidate optimal field design. Methods and Materials: We analyzed the 56 patients who underwent computed tomography-planned XRT for Stage I to III extremity STS between June 2000 and December 2006. Clinical target volume (CTV) included the T1 post-gadolinium-defined gross tumor volume with 1- to 1.5-cm radial and 3.5-cm longitudinal margins. Planning target volume expansion was 5 to 7 mm, and ≥95% of dose was delivered to the planning target volume. Preoperative XRT was 44 to 50.4 Gy (median, 50). Postoperative boost of 10 to 20 Gy was given to 12 patients (6 with positive and 6 with close margins). Results: Follow-up ranged from 15 to 76 months (median, 41 months). The 5-year local control, freedom from distant metastasis, disease-free survival, and overall survival were 88.5%, 80.0%, 77.5% and 82.8%, respectively. Three patients (all with positive margin) experienced local failure (LF) as first relapse (2 isolated, 1 with distant failure), and 2 additional patients (all with margin<1 mm) had late LF after distant metastasis. The LFs were within the CTV in 3 patients and within and also extending beyond the CTV in 2 patients. Conclusions: These target volume definitions appear to be appropriate for most patients. No local recurrences were observed with surgical margins ≥1 mm, and it appears that these may be adequate for patients with extremity STS treated with preoperative radiotherapy.

Original languageEnglish (US)
Pages (from-to)843-850
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number3
StatePublished - May 27 2010
Externally publishedYes



  • Extremity
  • Local failure
  • Preoperative radiotherapy
  • Radiation volume
  • Soft tissue sarcomas

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

Cite this

Kim, B. K., Chen, Y. L. E., Kirsch, D. G., Goldberg, S. I., Kobayashi, W., Kung, J. H., Wolfgang, J. A., Doppke, K., Rosenberg, A. E., Nielsen, G. P., Raskin, K. A., Springfield, D. S., Schwab, J. H., Gebhardt, M. C., Yoon, S. S., Hornicek, F. J., & DeLaney, T. F. (2010). An Effective Preoperative Three-Dimensional Radiotherapy Target Volume for Extremity Soft Tissue Sarcoma and the Effect of Margin Width on Local Control. International Journal of Radiation Oncology Biology Physics, 77(3), 843-850.