An automated method to detect interstitial adipose tissue in thigh muscles for patients with osteoarthritis

Jeffrey W. Prescott, Mike Priddy, Thomas Best, Michael Pennell, Mark S. Swanson, Furqan Haq, Rebecca D. Jackson, Metin N. Gurcan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

In this paper we explore a method of segmentation of muscle interstitial adipose tissue (IAT) in MR images of the thigh. The objective is to apply the method towards research into biomarkers of osteoarthritis (OA). T1-weighted images of the thigh are intensity standardized through bias field correction and intensity normalization. IAT within the thigh muscles is then segmented using a threshold combined with morphological constraints applied on connected regions in the thresholded image. The morphological constraints can be adjusted to allow for highly sensitive or highly specific IAT segmentation. The use of the morphological constraints improved the specificity of IAT segmentation over a threshold segmentation method from 0.54 to 0.67, while retaining a nearly equivalent sensitivity of 0.82 compared to 0.84. We then present a preliminary statistical analysis to demonstrate the application of the automated IAT segmentation. Finally, we specify a protocol for further exploration of IAT by leveraging the massive imaging dataset of the Osteoarthritis Initiative (OAI).

Original languageEnglish (US)
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationEngineering the Future of Biomedicine, EMBC 2009
PublisherIEEE Computer Society
Pages6360-6363
Number of pages4
ISBN (Print)9781424432967
DOIs
StatePublished - Jan 1 2009
Externally publishedYes
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

Fingerprint

Thigh
Osteoarthritis
Muscle
Adipose Tissue
Tissue
Muscles
Biomarkers
Statistical methods
Imaging techniques
Research

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

Cite this

Prescott, J. W., Priddy, M., Best, T., Pennell, M., Swanson, M. S., Haq, F., ... Gurcan, M. N. (2009). An automated method to detect interstitial adipose tissue in thigh muscles for patients with osteoarthritis. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 6360-6363). [5333260] IEEE Computer Society. https://doi.org/10.1109/IEMBS.2009.5333260

An automated method to detect interstitial adipose tissue in thigh muscles for patients with osteoarthritis. / Prescott, Jeffrey W.; Priddy, Mike; Best, Thomas; Pennell, Michael; Swanson, Mark S.; Haq, Furqan; Jackson, Rebecca D.; Gurcan, Metin N.

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, 2009. p. 6360-6363 5333260.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Prescott, JW, Priddy, M, Best, T, Pennell, M, Swanson, MS, Haq, F, Jackson, RD & Gurcan, MN 2009, An automated method to detect interstitial adipose tissue in thigh muscles for patients with osteoarthritis. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5333260, IEEE Computer Society, pp. 6360-6363, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5333260
Prescott JW, Priddy M, Best T, Pennell M, Swanson MS, Haq F et al. An automated method to detect interstitial adipose tissue in thigh muscles for patients with osteoarthritis. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society. 2009. p. 6360-6363. 5333260 https://doi.org/10.1109/IEMBS.2009.5333260
Prescott, Jeffrey W. ; Priddy, Mike ; Best, Thomas ; Pennell, Michael ; Swanson, Mark S. ; Haq, Furqan ; Jackson, Rebecca D. ; Gurcan, Metin N. / An automated method to detect interstitial adipose tissue in thigh muscles for patients with osteoarthritis. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, 2009. pp. 6360-6363
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