An augmented computer model of motor unit reorganization in neurogenic diseases of skeletal muscle

J. M. Lester, N. W. Soule, Walter G Bradley, J. F. Brenner

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A computer model of denervation and complete reinnervation in skeletal muscle was originally developed for the purpose of furthering an understanding of the underlying mechanisms of motor unit reorganization in neurogenic diseases. We now describe its successor, a computer model for investigating different rates of denervation and reinnervation, as well as incomplete reinnervation. The new model introduces the concept of permanent denervation and features enhanced interactive control over the distribution of motor unit centers and additional measures of dispersion and codispersion of muscle fibers. The use of this model for investigating pathophysiologically significant issues in denervating diseases is illustrated with five different sets of parameters. These simulate some of the processes that may be operational in chronic spinal muscular atrophy, amyotrophic lateral sclerosis, and progressive postpolio muscular dystrophy. The enhanced model will allow in-depth analysis of the influence of hypothesized pathophysiological processes on clinical, electrophysiological and pathological outcomes in human disease.

Original languageEnglish
Pages (from-to)43-56
Number of pages14
JournalMuscle and Nerve
Volume16
Issue number1
DOIs
StatePublished - Jan 13 1993

Fingerprint

Denervation
Computer Simulation
Skeletal Muscle
Spinal Muscular Atrophy
Muscular Dystrophies
Amyotrophic Lateral Sclerosis
Muscles

Keywords

  • computer model
  • denervation
  • motor unit
  • muscle, reinnervation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

An augmented computer model of motor unit reorganization in neurogenic diseases of skeletal muscle. / Lester, J. M.; Soule, N. W.; Bradley, Walter G; Brenner, J. F.

In: Muscle and Nerve, Vol. 16, No. 1, 13.01.1993, p. 43-56.

Research output: Contribution to journalArticle

@article{c9cdb4d6acde45189aac8353f35d6229,
title = "An augmented computer model of motor unit reorganization in neurogenic diseases of skeletal muscle",
abstract = "A computer model of denervation and complete reinnervation in skeletal muscle was originally developed for the purpose of furthering an understanding of the underlying mechanisms of motor unit reorganization in neurogenic diseases. We now describe its successor, a computer model for investigating different rates of denervation and reinnervation, as well as incomplete reinnervation. The new model introduces the concept of permanent denervation and features enhanced interactive control over the distribution of motor unit centers and additional measures of dispersion and codispersion of muscle fibers. The use of this model for investigating pathophysiologically significant issues in denervating diseases is illustrated with five different sets of parameters. These simulate some of the processes that may be operational in chronic spinal muscular atrophy, amyotrophic lateral sclerosis, and progressive postpolio muscular dystrophy. The enhanced model will allow in-depth analysis of the influence of hypothesized pathophysiological processes on clinical, electrophysiological and pathological outcomes in human disease.",
keywords = "computer model, denervation, motor unit, muscle, reinnervation",
author = "Lester, {J. M.} and Soule, {N. W.} and Bradley, {Walter G} and Brenner, {J. F.}",
year = "1993",
month = "1",
day = "13",
doi = "10.1002/mus.880160109",
language = "English",
volume = "16",
pages = "43--56",
journal = "Muscle and Nerve",
issn = "0148-639X",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - An augmented computer model of motor unit reorganization in neurogenic diseases of skeletal muscle

AU - Lester, J. M.

AU - Soule, N. W.

AU - Bradley, Walter G

AU - Brenner, J. F.

PY - 1993/1/13

Y1 - 1993/1/13

N2 - A computer model of denervation and complete reinnervation in skeletal muscle was originally developed for the purpose of furthering an understanding of the underlying mechanisms of motor unit reorganization in neurogenic diseases. We now describe its successor, a computer model for investigating different rates of denervation and reinnervation, as well as incomplete reinnervation. The new model introduces the concept of permanent denervation and features enhanced interactive control over the distribution of motor unit centers and additional measures of dispersion and codispersion of muscle fibers. The use of this model for investigating pathophysiologically significant issues in denervating diseases is illustrated with five different sets of parameters. These simulate some of the processes that may be operational in chronic spinal muscular atrophy, amyotrophic lateral sclerosis, and progressive postpolio muscular dystrophy. The enhanced model will allow in-depth analysis of the influence of hypothesized pathophysiological processes on clinical, electrophysiological and pathological outcomes in human disease.

AB - A computer model of denervation and complete reinnervation in skeletal muscle was originally developed for the purpose of furthering an understanding of the underlying mechanisms of motor unit reorganization in neurogenic diseases. We now describe its successor, a computer model for investigating different rates of denervation and reinnervation, as well as incomplete reinnervation. The new model introduces the concept of permanent denervation and features enhanced interactive control over the distribution of motor unit centers and additional measures of dispersion and codispersion of muscle fibers. The use of this model for investigating pathophysiologically significant issues in denervating diseases is illustrated with five different sets of parameters. These simulate some of the processes that may be operational in chronic spinal muscular atrophy, amyotrophic lateral sclerosis, and progressive postpolio muscular dystrophy. The enhanced model will allow in-depth analysis of the influence of hypothesized pathophysiological processes on clinical, electrophysiological and pathological outcomes in human disease.

KW - computer model

KW - denervation

KW - motor unit

KW - muscle, reinnervation

UR - http://www.scopus.com/inward/record.url?scp=0027444272&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027444272&partnerID=8YFLogxK

U2 - 10.1002/mus.880160109

DO - 10.1002/mus.880160109

M3 - Article

VL - 16

SP - 43

EP - 56

JO - Muscle and Nerve

JF - Muscle and Nerve

SN - 0148-639X

IS - 1

ER -