An association between autoreactive antibodies and anti-interferon-β antibodies in multiple sclerosis

Neeta Garg, B. Weinstock-Guttman, K. Bhasi, J. Locke, M. Ramanathan

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Approximately 5-25% of interferon-β (IFN-β) treated multiple sclerosis (MS) patients develop anti-IFN-β neutralizing antibodies (NAb) but the patient-specific variables associated with the risk of developing anti-IFN-β antibodies are poorly understood. Anti-IFN-β NAb are a subset of anti-IFN-β binding antibodies (BAb) and all patients with NAb generally have high levels of associated BAb. The purpose of this research was to assess the association between autoreactive antibodies (ARAB) and the risk of developing anti-IFN-β BAb in MS patients. This was a retrospective study that included consecutive patients diagnosed with clinically definite MS evaluated at our center and considered appropriate for IFN-β therapy. The patients were tested for various subtypes of antiphospholipid antibodies (APLA) including anti-phosphatidylethanolamine (APE), anti-phosphatidylserine (APS), and anti-cardiolipin (ACA) antibodies, and other ARAB, antinuclear and anti-neutrophilic cytoplasmic antibodies, anti-thyroid peroxidase antibodies (ATA), anti-SS-A and anti-SS-B antibodies. BAb levels were assessed using a commercial binding ELISA assay. A total of 33 patients (mean age: 45.4 years, 85% female) were enrolled; 15 patients were negative and 18 patients were positive for BAb. APLA or ATA were present in 95% (17 of 18 patients) of patients positive for BAb. In comparison, APLA or ATA occurred in only 27% (four of 15 patients) of patients in the BAb negative group. The associations between the occurrence of BAb and the occurrence of high APLA or ATA were significant (X2 = 13.4, P<0.001 in Fisher exact test). The odds ratio for the association was 46.8 (with a 95% confidence interval range of 4.6-475). No significant correlations were found for other ARAB. The presence of autoreactive antibodies, particularly APLA and ATA is associated with increased risk of occurrence of IFN-β BAb in MS patients on long-term IFN-β therapy.

Original languageEnglish (US)
Pages (from-to)895-899
Number of pages5
JournalMultiple Sclerosis
Volume13
Issue number7
DOIs
StatePublished - Aug 2007
Externally publishedYes

Keywords

  • Antiphospholipid antibody
  • Antithyroid antibody
  • Autoreactive antibody
  • Beta-interferon
  • Binding antibody
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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