An association between acute retinal necrosis syndrome and HLA-DQw7 and phenotype Bw62,DR4

G. N. Holland, P. J. Cornell, M. S. Park, A. Barbetti, J. Yuge, A. E. Kreiger, H. J. Kaplan, J. S. Pepose, J. R. Heckenlively, William W Culbertson, P. I. Terasaki

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48 Scopus citations


Human leukocyte antigen (HLA) typing was performed on 27 white patients with acute retinal necrosis syndrome. Antigens for the HLA-A, -B, -C, -DR and -DQ loci were determined, and frequencies were compared with racially matched controls. There was a statistically significant increase in the frequency of HLA-DQw7 (11 of 20 [55%] of patients vs 294 of 1546 [19%] of controls, P = .0004, relative risk 5.20) that remained significant at the P = .05 level when the P value was multiplied by the number of antigens tested. The HLA phenotype Bw62,DR4 is also more frequent than in normal control populations (4 of 25 [16%] of patients vs 26 of 1023 [2.6%] of controls, relatively risk 7.49). These results support an association between the acute retinal necrosis syndrome and certain HLA specificities and suggest a possible immunogenetic predisposition to the syndrome in some patients.

Original languageEnglish
Pages (from-to)370-374
Number of pages5
JournalAmerican Journal of Ophthalmology
Issue number4
StatePublished - Jan 1 1989
Externally publishedYes


ASJC Scopus subject areas

  • Ophthalmology

Cite this

Holland, G. N., Cornell, P. J., Park, M. S., Barbetti, A., Yuge, J., Kreiger, A. E., Kaplan, H. J., Pepose, J. S., Heckenlively, J. R., Culbertson, W. W., & Terasaki, P. I. (1989). An association between acute retinal necrosis syndrome and HLA-DQw7 and phenotype Bw62,DR4. American Journal of Ophthalmology, 108(4), 370-374.