An approach to the evaluation and treatment of Cushing's disease

Rebecca L. Brown, Roy E. Weiss

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Cushing's syndrome is an uncommon disorder involving dysregulation of the hypothalamic-pituitary-adrenal axis resulting in endogenous hypercortisolemia. It has multiple causes, but most commonly is due to hypersecretion of corticotropin from the pituitary gland, called Cushing's disease. The diagnosis of Cushing's syndrome remains a challenge to clinicians because routine hormonal assays can have significant overlap in pathological and normal states. We will review an approach to evaluating patients with suspected cortisol excess. We will also discuss treatment options and post-surgical assessment for those diagnosed with Cushing's disease.

Original languageEnglish (US)
Pages (from-to)S37-S46
JournalExpert review of anticancer therapy
Volume6
Issue number9 SUPPL.
DOIs
StatePublished - Sep 1 2006
Externally publishedYes

Keywords

  • Cushing's disease
  • Cushing's syndrome
  • Hypercortisolemia
  • Transsphenoidal surgery

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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