An AOP analysis of selective serotonin reuptake inhibitors (SSRIs) for fish

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

Pharmaceuticals and personal care products (PPCPs) are found in measureable quantities within the aquatic environment. Selective serotonin reuptake inhibitor (SSRI) antidepressants are one class of pharmaceutical compound that has received a lot of attention. Consistent with most PPCPs, the pharmacokinetics and physiological impacts of SSRI treatment have been well-studied in small mammals and humans and this, combined with the evolutionary conservation of the serotonergic system across vertebrates, allows for the read-across of known SSRI effects in mammals to potential SSRI impacts on aquatic organisms. Using an Adverse Outcome Pathway (AOP) framework, this review examines the similarities and differences between the mammalian and teleost fish SSRI target, the serotonin transporter (SERT; SLC6A4), and the downstream impacts of elevated extracellular serotonin (5-HT; 5-hydroxytryptamine), the consequence of SERT inhibition, on organ systems and physiological processes within teleost fish. This review also intends to reveal potentially understudied endpoints for SSRI toxicity based on what is known to be controlled by 5-HT in fish.

Original languageEnglish (US)
Pages (from-to)19-31
Number of pages13
JournalComparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology
Volume197
DOIs
StatePublished - Jul 1 2017

Keywords

  • 5-HT
  • Adverse Outcome Pathway
  • Antidepressant
  • Aquatic
  • Behavior
  • Fish
  • Fluoxetine
  • Physiology
  • Read-Across Hypothesis
  • SERT
  • Sertraline
  • Transport
  • Vertebrates

ASJC Scopus subject areas

  • Medicine(all)

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