An anti-inflammatory nanoscaffold for enhanced stem cell transplantation and neuronal differentiation post-spinal cord injury

Letao Yang, Susana R. Cerqueira, Jae K. Lee, Ki Bum Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Spinal cord injury (SCI) results in many cellular dysfunctions that may cause severe and permanent neurological deficits. Given the intrinsically limited regenerative potential of the spinal cord and the complex inhibitory environment created by SCI, neural stem cell (NSC)-based therapy holds a great clinical potential. However, several pertinent obstacles hinder successful transplantation strategies. First, due to strong neuro-inflammation post-SCI, most NSCs die soon after transplantation. Second, the extracellular matrix at SCI sites is not very conducive to NSC survival and differentiation. To this end, we developed a multifunctional nanomaterial-based bioscaffold methodology: i) for the controlled delivery of therapeutic molecules; ii) to incorporate the bioscaffold into the enhanced transplantation of stem cell-derived neurons; and iii) to evaluate the combined therapeutic effect of spatiotemporal delivery of therapeutic molecules and stem cell therapy for the effective treatment of SCI using a rodent SCI model. Considering the difficulties of generating a robust population of functional neurons, enhancing neuronal behaviors (neurite outgrowth and axon regeneration), our biodegradable hybrid nanoscaffold can serve as a powerful tool for achieving an improved SCI treatment.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Fingerprint

Stem Cell Transplantation
Stem cells
Spinal Cord Injuries
Anti-Inflammatory Agents
Neural Stem Cells
Cell- and Tissue-Based Therapy
Neurons
Transplantation
Nanostructures
Therapeutic Uses
Molecules
Therapeutics
Extracellular Matrix
Axons
Regeneration
Cell Differentiation
Nanostructured materials
Rodentia
Cell Survival
Spinal Cord

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Yang, L., Cerqueira, S. R., Lee, J. K., & Lee, K. B. (2019). An anti-inflammatory nanoscaffold for enhanced stem cell transplantation and neuronal differentiation post-spinal cord injury. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.

An anti-inflammatory nanoscaffold for enhanced stem cell transplantation and neuronal differentiation post-spinal cord injury. / Yang, Letao; Cerqueira, Susana R.; Lee, Jae K.; Lee, Ki Bum.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yang, L, Cerqueira, SR, Lee, JK & Lee, KB 2019, An anti-inflammatory nanoscaffold for enhanced stem cell transplantation and neuronal differentiation post-spinal cord injury. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.
Yang L, Cerqueira SR, Lee JK, Lee KB. An anti-inflammatory nanoscaffold for enhanced stem cell transplantation and neuronal differentiation post-spinal cord injury. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
Yang, Letao ; Cerqueira, Susana R. ; Lee, Jae K. ; Lee, Ki Bum. / An anti-inflammatory nanoscaffold for enhanced stem cell transplantation and neuronal differentiation post-spinal cord injury. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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