An Anisotropic Multiphysics Model for Intervertebral Disk

Xin Gao, Qiaoqiao Zhu, Weiyong Gu

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Intervertebral disk (IVD) is the largest avascular structure in human body, consisting of three types of charged hydrated soft tissues. Its mechanical behavior is nonlinear and anisotropic, due mainly to nonlinear interactions among different constituents within tissues. In this study, a more realistic anisotropic multiphysics model was developed based on the continuum mixture theory and employed to characterize the couplings of multiple physical fields in the IVD. Numerical simulations demonstrate that this model is capable of systematically predicting the mechanical and electrochemical signals within the disk under various loading conditions, which is essential in understanding the mechanobiology of IVD.

Original languageEnglish (US)
Article number021001
JournalJournal of Applied Mechanics, Transactions ASME
Issue number2
StatePublished - Feb 1 2016


  • anisotropic diffusivity
  • anisotropic permeability
  • biomechanics
  • mixture theory
  • multiphase

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


Dive into the research topics of 'An Anisotropic Multiphysics Model for Intervertebral Disk'. Together they form a unique fingerprint.

Cite this