An Anisotropic Multiphysics Model for Intervertebral Disk

Xin Gao, Qiaoqiao Zhu, Weiyong Gu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Intervertebral disk (IVD) is the largest avascular structure in human body, consisting of three types of charged hydrated soft tissues. Its mechanical behavior is nonlinear and anisotropic, due mainly to nonlinear interactions among different constituents within tissues. In this study, a more realistic anisotropic multiphysics model was developed based on the continuum mixture theory and employed to characterize the couplings of multiple physical fields in the IVD. Numerical simulations demonstrate that this model is capable of systematically predicting the mechanical and electrochemical signals within the disk under various loading conditions, which is essential in understanding the mechanobiology of IVD.

Original languageEnglish (US)
Article number021001
JournalJournal of Applied Mechanics, Transactions ASME
Volume83
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

intervertebral disks
Tissue
human body
Computer simulation
continuums
simulation
interactions

Keywords

  • anisotropic diffusivity
  • anisotropic permeability
  • biomechanics
  • mixture theory
  • multiphase

ASJC Scopus subject areas

  • Mechanical Engineering
  • Mechanics of Materials
  • Condensed Matter Physics

Cite this

An Anisotropic Multiphysics Model for Intervertebral Disk. / Gao, Xin; Zhu, Qiaoqiao; Gu, Weiyong.

In: Journal of Applied Mechanics, Transactions ASME, Vol. 83, No. 2, 021001, 01.02.2016.

Research output: Contribution to journalArticle

@article{b9888b173955468bab3e8f77dfad7b2c,
title = "An Anisotropic Multiphysics Model for Intervertebral Disk",
abstract = "Intervertebral disk (IVD) is the largest avascular structure in human body, consisting of three types of charged hydrated soft tissues. Its mechanical behavior is nonlinear and anisotropic, due mainly to nonlinear interactions among different constituents within tissues. In this study, a more realistic anisotropic multiphysics model was developed based on the continuum mixture theory and employed to characterize the couplings of multiple physical fields in the IVD. Numerical simulations demonstrate that this model is capable of systematically predicting the mechanical and electrochemical signals within the disk under various loading conditions, which is essential in understanding the mechanobiology of IVD.",
keywords = "anisotropic diffusivity, anisotropic permeability, biomechanics, mixture theory, multiphase",
author = "Xin Gao and Qiaoqiao Zhu and Weiyong Gu",
year = "2016",
month = "2",
day = "1",
doi = "10.1115/1.4031793",
language = "English (US)",
volume = "83",
journal = "Journal of Applied Mechanics, Transactions ASME",
issn = "0021-8936",
publisher = "American Society of Mechanical Engineers(ASME)",
number = "2",

}

TY - JOUR

T1 - An Anisotropic Multiphysics Model for Intervertebral Disk

AU - Gao, Xin

AU - Zhu, Qiaoqiao

AU - Gu, Weiyong

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Intervertebral disk (IVD) is the largest avascular structure in human body, consisting of three types of charged hydrated soft tissues. Its mechanical behavior is nonlinear and anisotropic, due mainly to nonlinear interactions among different constituents within tissues. In this study, a more realistic anisotropic multiphysics model was developed based on the continuum mixture theory and employed to characterize the couplings of multiple physical fields in the IVD. Numerical simulations demonstrate that this model is capable of systematically predicting the mechanical and electrochemical signals within the disk under various loading conditions, which is essential in understanding the mechanobiology of IVD.

AB - Intervertebral disk (IVD) is the largest avascular structure in human body, consisting of three types of charged hydrated soft tissues. Its mechanical behavior is nonlinear and anisotropic, due mainly to nonlinear interactions among different constituents within tissues. In this study, a more realistic anisotropic multiphysics model was developed based on the continuum mixture theory and employed to characterize the couplings of multiple physical fields in the IVD. Numerical simulations demonstrate that this model is capable of systematically predicting the mechanical and electrochemical signals within the disk under various loading conditions, which is essential in understanding the mechanobiology of IVD.

KW - anisotropic diffusivity

KW - anisotropic permeability

KW - biomechanics

KW - mixture theory

KW - multiphase

UR - http://www.scopus.com/inward/record.url?scp=84946882137&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946882137&partnerID=8YFLogxK

U2 - 10.1115/1.4031793

DO - 10.1115/1.4031793

M3 - Article

AN - SCOPUS:84946882137

VL - 83

JO - Journal of Applied Mechanics, Transactions ASME

JF - Journal of Applied Mechanics, Transactions ASME

SN - 0021-8936

IS - 2

M1 - 021001

ER -