An analysis of lymphocytes with both T-cell marker and IgG or complement receptors in patients with X-linked agammaglobulinemia

Jen Wei Chiao; Joáo Ascensáo; Savita Pahwa; Rajendra Pahwa; Robert A. Good

doi:10.1016/0090-1229(76)90104-5

An analysis of lymphocytes with both T-cell marker and IgG or complement receptors in patients with X-linked agammaglobulinemia

Jen Wei Chiao, Joáo Ascensáo, Savita Pahwa, Rajendra Pahwa, Robert A. Good

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

By a mixed rosette technique, a small population of lymphocytes possessing both the T-cell characteristic of spontaneous rosette formation with sheep erythrocytes and B-cell membrane receptors for IgG or complement was found in the peripheral blood of all four patients with X-linked infantile agammaglobulinemia. The relative proportions of these lymphocytes, tentatively called D-lymphocytes, are comparable to those of healthy persons. Both the surface receptor features of D-lymphocytes and the presence of these cells in patients lacking B-lymphocytes suggest that these lymphocytes may be independent of the B-lymphocyte population.

Original language	English (US)
Pages (from-to)	141-148
Number of pages	8
Journal	Clinical Immunology and Immunopathology
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/0090-1229(76)90104-5
State	Published - Sep 1976
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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@article{209af87fe6e44dd9b2e450ec729b4d37,

title = "An analysis of lymphocytes with both T-cell marker and IgG or complement receptors in patients with X-linked agammaglobulinemia",

abstract = "By a mixed rosette technique, a small population of lymphocytes possessing both the T-cell characteristic of spontaneous rosette formation with sheep erythrocytes and B-cell membrane receptors for IgG or complement was found in the peripheral blood of all four patients with X-linked infantile agammaglobulinemia. The relative proportions of these lymphocytes, tentatively called D-lymphocytes, are comparable to those of healthy persons. Both the surface receptor features of D-lymphocytes and the presence of these cells in patients lacking B-lymphocytes suggest that these lymphocytes may be independent of the B-lymphocyte population.",

author = "Chiao, {Jen Wei} and Jo{\'a}o Ascens{\'a}o and Savita Pahwa and Rajendra Pahwa and Good, {Robert A.}",

note = "Funding Information: This research was supported by Public Health Service Research Grant No. CA-17404 from the National Cancer Institute, by a grant from the National Foundation-March of Dimes, and by Public Health Service Research Grant No. ROl AI-12843-01 ALY from the Department of Health, Education and Welfare. Joao Ascensao was supported by a grant from the Instituto de Alta Cultura, Lisbon, Portugal. We thank Ms. R. Nemirow and Ms. Maxine Goldberg for their assistance in preparing this manuscript. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1976",

month = sep,

doi = "10.1016/0090-1229(76)90104-5",

language = "English (US)",

volume = "6",

pages = "141--148",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - An analysis of lymphocytes with both T-cell marker and IgG or complement receptors in patients with X-linked agammaglobulinemia

AU - Chiao, Jen Wei

AU - Ascensáo, Joáo

AU - Pahwa, Savita

AU - Pahwa, Rajendra

AU - Good, Robert A.

N1 - Funding Information: This research was supported by Public Health Service Research Grant No. CA-17404 from the National Cancer Institute, by a grant from the National Foundation-March of Dimes, and by Public Health Service Research Grant No. ROl AI-12843-01 ALY from the Department of Health, Education and Welfare. Joao Ascensao was supported by a grant from the Instituto de Alta Cultura, Lisbon, Portugal. We thank Ms. R. Nemirow and Ms. Maxine Goldberg for their assistance in preparing this manuscript. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1976/9

Y1 - 1976/9

N2 - By a mixed rosette technique, a small population of lymphocytes possessing both the T-cell characteristic of spontaneous rosette formation with sheep erythrocytes and B-cell membrane receptors for IgG or complement was found in the peripheral blood of all four patients with X-linked infantile agammaglobulinemia. The relative proportions of these lymphocytes, tentatively called D-lymphocytes, are comparable to those of healthy persons. Both the surface receptor features of D-lymphocytes and the presence of these cells in patients lacking B-lymphocytes suggest that these lymphocytes may be independent of the B-lymphocyte population.

AB - By a mixed rosette technique, a small population of lymphocytes possessing both the T-cell characteristic of spontaneous rosette formation with sheep erythrocytes and B-cell membrane receptors for IgG or complement was found in the peripheral blood of all four patients with X-linked infantile agammaglobulinemia. The relative proportions of these lymphocytes, tentatively called D-lymphocytes, are comparable to those of healthy persons. Both the surface receptor features of D-lymphocytes and the presence of these cells in patients lacking B-lymphocytes suggest that these lymphocytes may be independent of the B-lymphocyte population.

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