By a mixed rosette technique, a small population of lymphocytes possessing both the T-cell characteristic of spontaneous rosette formation with sheep erythrocytes and B-cell membrane receptors for IgG or complement was found in the peripheral blood of all four patients with X-linked infantile agammaglobulinemia. The relative proportions of these lymphocytes, tentatively called D-lymphocytes, are comparable to those of healthy persons. Both the surface receptor features of D-lymphocytes and the presence of these cells in patients lacking B-lymphocytes suggest that these lymphocytes may be independent of the B-lymphocyte population.
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine