An analysis of lymphocytes with both T-cell marker and IgG or complement receptors in patients with X-linked agammaglobulinemia

Jen Wei Chiao, Joáo Ascensáo, Savita Pahwa, Rajendra Pahwa, Robert A. Good

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

By a mixed rosette technique, a small population of lymphocytes possessing both the T-cell characteristic of spontaneous rosette formation with sheep erythrocytes and B-cell membrane receptors for IgG or complement was found in the peripheral blood of all four patients with X-linked infantile agammaglobulinemia. The relative proportions of these lymphocytes, tentatively called D-lymphocytes, are comparable to those of healthy persons. Both the surface receptor features of D-lymphocytes and the presence of these cells in patients lacking B-lymphocytes suggest that these lymphocytes may be independent of the B-lymphocyte population.

Original languageEnglish (US)
Pages (from-to)141-148
Number of pages8
JournalClinical Immunology and Immunopathology
Volume6
Issue number2
DOIs
StatePublished - Sep 1976
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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