An acquired robertsonian translocation dic(14;14)(p11;p11) in a patient with a myelodysplastic syndrome following treatment of multiple myeloma

Yao Shan Fan, Maria R. Baer, Sheila N. Jani Sait, Paola Dal Cin, Theodore C. Prentice, Harvey D. Preisler, Avery A. Sandberg

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Acquired Robertsonian translocations are considered to be very rare chromosome changes in human malignancy, and only three cases have been described. We report a dic(14;14)(p11;p11) in a patient with myelodysplastic syndromes (MDS) following treatment for multiple myeloma. This patient also had other complex chromosomal abnormalities. The pattern of karyotype evolution in this patient was established by a series of cytogenetic studies. The relationship of the complex chromosomal changes to MDS following treatment for multiple myeloma is discussed.

Original languageEnglish (US)
Pages (from-to)133-137
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume30
Issue number1
DOIs
StatePublished - Jan 1988
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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